Soluble Prorenin Receptor Increases Blood Pressure in High Fat-Fed Male Mice

Hypertension
Eva GatineauFrédérique Yiannikouris

Abstract

Obesity-related hypertension is a major public health concern. We recently demonstrated that plasma levels of the soluble form of the prorenin receptor (sPRR) were elevated in obesity-associated hypertension. Therefore, in the present study, we investigated the contribution of sPRR to blood pressure (BP) elevation in the context of obesity. High fat-fed C57BL/6 male mice were infused with vehicle or sPRR (30 µg/kg per day) via subcutaneously implanted osmotic minipump for 4 weeks. BP parameters were recorded using radiotelemetry devices. Male mice infused with sPRR exhibited higher systolic BP and mean arterial pressure and lower spontaneous baroreflex sensitivity than mice infused with vehicle. To define mechanisms involved in systolic BP elevation, mice were injected with an AT1R (Ang II [angiotensin II] type 1 receptor) antagonist (losartan), a muscarinic receptor antagonist (atropine), a β-adrenergic antagonist (propranolol), and a ganglionic blocker (chlorisondamine). Losartan did not blunt sPRR-induced elevation in systolic BP. Chlorisondamine treatment exacerbated the decrease in mean arterial pressure in male mice infused with sPRR. These results demonstrated that sPRR induced autonomic nervous dysfunction. Interestingl...Continue Reading

References

Feb 7, 1998·Hypertension·E W ShekJ E Hall
Jan 2, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vincent AchardMichel Grino
Mar 17, 2007·Neuroscience Letters·Takuo NakamuraKatsuya Nagai
Apr 18, 2007·Hypertension·Thomas E LohmeierRobert S Kieval
May 16, 2009·Current Hypertension Reports·Alexandre A da SilvaJohn E Hall
Jan 29, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ayumu YoshikawaTakaaki Senbonmatsu
Mar 18, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazal Boron BiswasFumiaki Suzuki
Apr 14, 2012·European Urology·Charles D ScalesUNKNOWN Urologic Diseases in America Project
May 9, 2012·Hypertension·Brent M EganKristina S Yu-Isenberg
Oct 10, 2012·Hypertension·Noriyoshi WatanabeAtsuhiro Ichihara
May 16, 2013·International Journal of Cardiology·Arata FukushimaHiroyuki Tsutsui
Mar 22, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi MorimotoAtsuhiro Ichihara
Sep 18, 2014·Bioscience, Biotechnology, and Biochemistry·Chiharu Suzuki-NakagawaTsutomu Nakagawa
Dec 2, 2014·Autonomic Neuroscience : Basic & Clinical·Virginia L BrooksPaul J Fadel
Mar 15, 2015·Circulation Research·Guido GrassiMurray Esler
Apr 22, 2015·European Journal of Pharmacology·Meng-Kwoon Sim
Jun 28, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Michael J HuberZhiying Shan
Mar 5, 2016·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Gino Seravalle, Guido Grassi
Mar 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Xiaohan LuTianxin Yang
Aug 12, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lia E Taylor, Jennifer C Sullivan
Nov 15, 2017·Hypertension·Jessica L Faulkner, Eric J Belin de Chantemèle
Dec 15, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Eva GatineauFrédérique Yiannikouris

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Citations

Jan 12, 2020·Current Hypertension Reports·Pablo NakagawaCurt D Sigmund
Dec 17, 2019·American Journal of Physiology. Renal Physiology·Fei WangTianxin Yang
Sep 26, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yanting Chen, Chuanming Xu
Apr 22, 2020·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Moe EndoKazuhiro Takahashi
Sep 14, 2020·Placenta·Saije K MorosinKirsty G Pringle
Jan 21, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gertrude ArthurFrédérique B Yiannikouris
Mar 30, 2021·Journal of Experimental Pharmacology·Syed S QuadriLudmila Nahar
Apr 24, 2021·Circulation Research·Nirupama RamkumarDonald E Kohan
Jun 24, 2021·The Journal of Pharmacology and Experimental Therapeutics·Manman QinJun Yu
Oct 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Youyou LiYingxian Li
Apr 27, 2021·Clinical Science·Raquel González-BlázquezBeatriz Somoza

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