PMID: 92993Dec 1, 1979Paper

Soluble proteins in the human atherosclerotic plaque. With spectral reference to immunoglobulins, C3-complement component, alpha 1-antitrypsin and alpha 2-macroglobulin

Atherosclerosis
W HollanderJ Paddock

Abstract

A number of soluble proteins contained in human aortic intimal tissue was extracted into buffered saline (pH 7.4) and identified and quantitated by immunoelectrophoresis and immunodiffusion. The proteins included IgA, IgG, IgM, B1C (C3), alpha 1-antitrypsin, alpha 2-macroglobulin, fibrinogen, albumin, LDL, HDL, alpha 1-acid glycoprotein, beta 2-glycoprotein, transferrin and ceruloplasmin. The concentration of soluble proteins was significantly higher in the atherosclerotic intima than in the normal intima. The diseased intima also contained a small amount of tissue-bound IgG, IgA and B1C which was extractable with citrate buffer at pH 3.2. The vascular band IgG, and B1C were shown by enzymatic and immunohistochemical studies to be closely associated with the collagenous tissue of the plaque. The Ig contained in the atherosclerotic plaque may be derived in part from the biosynthesis of Ig by the artery, since the incorporation of 14C-labeled leucine into IgG by the atheromatous plaque was demonstrable by radioimmunoelectrophoresis. In contrast to the diseased artery, the normal artery did not synthesize IgG and did not contain vascular bound IgG or complement. However, the normal artery was capable of fixing IgG and B1C eluted f...Continue Reading

References

Mar 25, 1978·Lancet·T L Dormandy
Feb 1, 1977·The Journal of Clinical Investigation·I M GoldsteinH B Kaplan
Dec 5, 1970·Lancet·D J GockeC L Christian
Mar 1, 1970·Circulation·J D MilamD A Cooley
Dec 1, 1971·Annals of Internal Medicine·M Ziff
Jul 12, 1973·The New England Journal of Medicine·T StarzlH L Sharp
Mar 28, 1974·The New England Journal of Medicine·T P Stossel
Sep 5, 1974·The New England Journal of Medicine·R W Colman
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Feb 1, 1970·The Journal of Clinical Investigation·J J McPhaul, F J Dixon
Sep 1, 1968·The Journal of Experimental Medicine·M Van Winkle, L Levy
Oct 1, 1960·The Journal of Pathology and Bacteriology·N WOOLF, T CRAWFORD
Sep 14, 1963·British Medical Journal·K A PORTERW S PEART
Feb 1, 1965·The Journal of Experimental Medicine·P A WARD, C G COCHRANE
Jul 1, 1965·Archives of Environmental Health·P GROSSM KASCHAK

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Citations

Nov 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·P S Seifert, G K Hansson
Sep 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G K HanssonS Stemme
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S Ylä-HerttualaJ L Witztum
Jan 29, 2013·Annual Review of Biochemistry·Amy R WyattMark R Wilson
Jan 3, 2013·Diabetes/metabolism Research and Reviews·Takayuki FujitaMasayoshi Soma
May 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Amy R WyattChristopher M Dobson
Jul 24, 2014·BioMed Research International·Igor A SobeninAlexander N Orekhov
Jun 21, 2015·Immunologic Research·Sonia I VlaicuHorea Rus
Nov 10, 2018·Nature Reviews. Cardiology·Andrew P SageZiad Mallat
May 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R W JamesD Hochstrasser
Jan 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A BiniK L Kaplan
May 1, 1993·Scandinavian Journal of Immunology·J P López-BoteC Bernabéu
Jan 1, 1983·Critical Reviews in Toxicology·D M Klurfeld
Jun 25, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Johan Frostegård
Aug 11, 2015·Journal of Cellular and Molecular Medicine·Olle MelanderAntonio J López-Farré
Jan 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·J R Guyton, K F Klemp
Mar 15, 1982·Experientia·J CopelandL C Ginsberg
Mar 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A N OrekhovV N Smirnov
Oct 16, 1999·European Journal of Biochemistry·S Janciauskiene, S Lindgren
Mar 6, 1999·Stroke; a Journal of Cerebral Circulation·M SawadaR L Macdonald
Apr 30, 2009·Proteomics·Matthew R RichardsonFrank A Witzmann
Dec 25, 2009·Circulation. Cardiovascular Genetics·Manuel MayrChantal M Boulanger
Sep 17, 2013·Circulation Research·Gaël BoriesGiulia Chinetti-Gbaguidi
Oct 18, 2012·Journal of Clinical Immunology·Igor A SobeninAlexander N Orekhov
Feb 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·X A LiA Yamamoto
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·C K MukhopadhyayP L Fox
Mar 18, 2005·The Journal of Pathology·Marjo M P C DonnersSylvia Heeneman
Sep 23, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Göran K Hansson
Oct 10, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Masayoshi KobayashiKimihiro Komori
Apr 17, 2010·Angiology·Dayangku Fatiha Pengiran BurutGordon A A Ferns
Oct 15, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Masayoshi NanamiTakeshi Nakanishi

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