Soluble ST2 Is Associated With New Epileptiform Abnormalities Following Nontraumatic Subarachnoid Hemorrhage.

Stroke; a Journal of Cerebral Circulation
India A LissakEric S Rosenthal

Abstract

Background and Purpose- We evaluated the association between 2 types of predictors of delayed cerebral ischemia after nontraumatic subarachnoid hemorrhage, including biomarkers of the innate immune response and neurophysiologic changes on continuous electroencephalography. Methods- We studied subarachnoid hemorrhage patients that had at least 72 hours of continuous electroencephalography and blood samples collected within the first 5 days of symptom onset. We measured inflammatory biomarkers previously associated with delayed cerebral ischemia and functional outcome, including soluble ST2 (sST2), IL-6 (interleukin-6), and CRP (C-reactive protein). Serial plasma samples and cerebrospinal fluid sST2 levels were available in a subgroup of patients. Neurophysiologic changes were categorized into new or worsening epileptiform abnormalities (EAs) or new background deterioration. The association of biomarkers with neurophysiologic changes were evaluated using the Wilcoxon rank-sum test. Plasma and cerebrospinal fluid sST2 were further examined longitudinally using repeated measures mixed-effects models. Results- Forty-six patients met inclusion criteria. Seventeen (37%) patients developed new or worsening EAs, 21 (46%) developed new b...Continue Reading

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Citations

Feb 3, 2021·Current Neurology and Neuroscience Reports·Brandon ForemanEric S Rosenthal
Apr 27, 2021·Neurologic Clinics·David Y ChungThanh N Nguyen
Jun 4, 2021·Frontiers in Immunology·Yun SunXiaofeng Yang
Oct 8, 2021·Continuum : Lifelong Learning in Neurology·Eric S Rosenthal

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