Soluble sugar-based quinoline derivatives as new antioxidant modulators of metal-induced amyloid aggregation

Inorganic Chemistry
Valentina OliveriGraziella Vecchio

Abstract

Oxidative stress and protein aggregation have been demonstrated to be the major factors involved in neurodegenerative diseases. Metal ions play a pivotal role, acting as mediators of neurotoxicity either by favoring or redox cycling. Thus, they represent a promising and suitable therapeutic target for the treatment of neurodegenerative disorders. In particular, the development of bifunctional or multifunctional molecules, which have antiaggregant and metal-chelating/antioxidant properties, may be considered as a valuable strategy for the treatment of neurodegeneration considering its multifactorial nature. Herein, we report the design and the characterization of four new multifunctional sugar-appended 8-hydroxyquinolines focusing on the effects of the conjugation with trehalose, a nonreducing disaccharide involved in the protection of proteins and cells against environmental stresses. These glycoconjugates do not exhibit any antiproliferative activity against three human cell lines of different histological origin, unlike 8-hydroxyquinolines. The multiple properties of the new derivatives are highlighted, reporting their Cu(2+) and Zn(2+) binding ability, and antioxidant and antiaggregant capacities. In particular, these latter...Continue Reading

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Citations

May 19, 2016·European Journal of Medicinal Chemistry·Valentina Oliveri, Graziella Vecchio
May 14, 2016·Future Medicinal Chemistry·Hironari Akasaka, Ke-He Ruan
Feb 6, 2017·Chemistry : a European Journal·Valentina OliveriGraziella Vecchio
Aug 25, 2015·Chemistry : a European Journal·Valentina OliveriGraziella Vecchio
Apr 25, 2019·International Journal of Molecular Sciences·Thais A SalesTeodorico C Ramalho
Jun 26, 2020·Chembiochem : a European Journal of Chemical Biology·Ivana DrienovskáGerard Roelfes
Apr 3, 2016·Chemistry, an Asian Journal·Valentina Oliveri, Graziella Vecchio
Sep 22, 2017·Metallomics : Integrated Biometal Science·Valentina OliveriGraziella Vecchio
Apr 7, 2018·Chemistry : a European Journal·Valentina OliveriGraziella Vecchio
Dec 18, 2018·Investigational New Drugs·Maurizio VialeGraziella Vecchio
Jul 7, 2020·Chemistry : a European Journal·Francesco BelliaGraziella Vecchio
May 21, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaohui WangZhi Yuan
Jun 27, 2015·Journal of Inorganic Biochemistry·Valeria LanzaGraziella Vecchio
Sep 3, 2021·Future Medicinal Chemistry·Nilesh Gajanan BajadSushil Kumar Singh

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