Abstract
Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is a potential and novel biomarker of neuroinflammation implicated in the onset and progression of Alzheimer's disease (AD). However, previous studies evaluating levels of sTREM2 in different clinical stages of AD have yielded inconsistent results. To clarify the dynamic change of sTREM2 in AD progression, we conducted a meta-analysis of case-control and cohort studies to determine the role of cerebral spinal fluid (CSF) and plasma sTREM2 levels in preclinical AD (pre-AD), mild cognitive impairment (MCI) and AD dementia. We searched PubMed, MEDLINE, EMBASE, the Cochrane Library for English articles and Sinomed, CNKI for Chinese. The associations between sTREM2 levels and AD continuum groups (pre-AD, MCI and AD) were analyzed. We further performed detailed subgroup analysis and meta-regression to detect the sources of heterogeneity. 17 reports comprising 82 patients with pre-AD, 159 with MCI, 598 with AD, as well as 754 controls were included in this analysis. Regarding the sTREM2 levels in CSF, the overall pooled standard mean difference (SMD) revealed significantly elevated sTREM2 levels in the whole AD continuum groups (SMD = 0.48; 95% CI: 0.23, 0.73; P < 0.001...Continue Reading
References
Jul 1, 1984·Neurology·G McKhannE M Stadlan
Mar 14, 2000·Archives of Neurology·N C FoxM N Rossor
Jul 28, 2005·The Journal of Biological Chemistry·Yoonji KimHiroshi Takayanagi
Oct 24, 2007·Immunology Letters·M MottaL Malaguarnera
Jun 14, 2008·Glia·Stefanie FrankThomas Deller
Sep 16, 2008·Brain : a Journal of Neurology·Laura PiccioAnne H Cross
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Apr 26, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Reisa A SperlingCreighton H Phelps
Apr 29, 2011·PloS One·Rebecca Craig-SchapiroDavid M Holtzman
Aug 20, 2011·Nature Reviews. Drug Discovery·Eric KarranBart De Strooper
Jan 24, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bradley T HymanThomas J Montine
Mar 23, 2012·Journal of Neuropathology and Experimental Neurology·Thomas G BeachWalter Kukull
Apr 17, 2012·Neurobiology of Aging·Joshua D GrillUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 18, 2012·Personality Disorders·Timothy J TrullKenneth J Sher
Nov 16, 2012·The New England Journal of Medicine·Thorlakur JonssonKari Stefansson
Jul 17, 2013·Neurobiology of Aging·Paola ForaboscoMina Ryten
Sep 5, 2013·Journal of Alzheimer's Disease : JAD·Nan HuLan Tan
Oct 1, 2013·The Journal of Biological Chemistry·Patrick WunderlichJochen Walter
Feb 26, 2014·Molecular Neurobiology·Frederic BrosseronMichael T Heneka
Jun 26, 2014·Nature Reviews. Immunology·Michael T HenekaEicke Latz
Jul 6, 2014·Science Translational Medicine·Gernot KleinbergerChristian Haass
Jan 13, 2016·Molecular Neurodegeneration·Amanda HeslegraveHenrik Zetterberg
Jan 13, 2016·Acta Neuropathologica·Laura PiccioCarlos Cruchaga
Jan 13, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Annika ÖhrfeltHenrik Zetterberg
Feb 9, 2016·ACS Chemical Neuroscience·Jason D Ulrich, David M Holtzman
Mar 5, 2016·EMBO Molecular Medicine·Marc Suárez-CalvetChristian Haass
Apr 29, 2016·Alzheimer's Research & Therapy·Kristi HenjumLars N G Nilsson
Jul 18, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Juan Domingo GispertJosé Luis Molinuevo
Feb 6, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Juan Domingo GispertJosé Luis Molinuevo
Feb 18, 2017·The Journal of Experimental Medicine·Li ZhongGuojun Bu
Dec 25, 2017·Experimental Gerontology·Aurélie Le PageTamas Fulop
Citations
Jan 24, 2019·Journal of Neurovirology·Leah H RubinDavid J Moore
Jan 22, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Grace E WeberLynn M Bekris
Mar 5, 2020·Expert Opinion on Therapeutic Targets·Shehata Anwar, Serge Rivest
Mar 14, 2020·Clinical Science·Miroslava KacířováLenka Maletínská
Jul 8, 2020·International Journal of Molecular Sciences·Xavier O ScottJuan Pablo de Rivero Vaccari
Jul 16, 2020·Journal of Personalized Medicine·Chiara VillaRomina Combi
Sep 29, 2020·Scientific Reports·Anne-Brita KnapskogLars N G Nilsson
May 20, 2020·Translational Psychiatry·André F CarvalhoNathan Herrmann
Jul 9, 2020·Journal of Neuroinflammation·Jiaolong YangZhentao Zhang
Feb 23, 2019·Journal of Neuroinflammation·Kaja NordengenTormod Fladby
Aug 6, 2019·Frontiers in Immunology·Pascal Gervois, Ivo Lambrichts
Jul 22, 2019·Cells·Onanong Mee-IntaYu-Min Kuo
Feb 11, 2020·Frontiers in Aging Neuroscience·Li Zhong, Xiao-Fen Chen
Jan 12, 2019·Molecular Neurodegeneration·Marc Suárez-CalvetUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jan 4, 2020·Therapeutic Advances in Neurological Disorders·Marta Milà-AlomàJosé Luís Molinuevo
Dec 28, 2018·International Journal of Molecular Sciences·Cody M WolfeRadosveta Koldamova
Nov 12, 2019·Frontiers in Aging Neuroscience·Changan Liu, Jun Yu
Feb 14, 2021·Brain Sciences·Donovan A McGrowderRuby Alexander-Lindo
Feb 1, 2021·Mechanisms of Ageing and Development·Qi QinYi Tang
Mar 27, 2021·Frontiers in Molecular Biosciences·Evelyn FerriBeatrice Arosio
Apr 1, 2021·The European Journal of Neuroscience·Sadat ShafiFaheem Hyder Pottoo
Apr 27, 2021·Neurobiology of Aging·Emma L van der EndeHarro Seelaar
May 14, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·David G Morgan, Michelle M Mielke
May 14, 2021·Frontiers in Aging Neuroscience·Ryuzo OrihashiAkira Monji
Jun 13, 2020·Cell·Aleksandra DeczkowskaIdo Amit
Jun 24, 2021·Scientific Reports·So-Hee ParkJae-Hong Lee
Aug 28, 2021·Nature Medicine·Tharick A PascoalPedro Rosa-Neto
Sep 2, 2021·Journal of Neuroinflammation·Hongyoon ChoiUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 14, 2021·Brain : a Journal of Neurology·Hsin-Hsi TsaiChe-Feng Chang
Dec 7, 2021·Frontiers in Aging Neuroscience·Shimin HuTingting Zhang
Dec 17, 2021·Human Brain Mapping·Bingyu RenJiazuan Ni