journal cover

Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau

Brain : a Journal of Neurology

Feb 18, 2020

Edward N. WilsonKatrin I. Andreasson

Download from

Publisher
PubMed

Abstract

Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease and affects 1% of the population above 60 years old. Although Parkinson's disease commonly manifests with motor symptoms, a majority of patients with Parkinson's disease subsequently develo...read more

Mentioned in this Paper

Parkinson Disease
Protein Expression
Amyloid beta-Peptides
Neurodegenerative Disorders
Alzheimer's Disease
Participant
Dementia
Population Group
Granulocyte Colony-Stimulating Factor
Receptor
59
1
1
Paper Details
References
  • References55
  • Citations
12345...
  • References55
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Feeds With Similar Papers

Synucleinopathies

Synucleinopathies are neurodegenerative diseases characterized by accumulation of alpha-synuclein protein aggregates in neurons and glial cells. Discover the latest research on synucleinopathies here.

Tau Aggregation: Genomics

Tau Aggregation is an important characteristic in some neurodegenerative disorders, including Alzheimer’s Disease. Discover the latest research using genomics to understand Tau Aggregation.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on the underlying role of Tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's.

Parkinson's Disease

Parkinson's Disease is a progressive neurodegenerative disorder characterized by loss of muscle control, including trembling of the limbs and impaired balance. Here is the latest research.

Galectins & Alpha-Synuclein (MDS)

Galectins proteins bind to sugar molecules and mediate the cellular response to endocytic vesicles. It is believed that some galectin proteins are involved in microglia activation induced by α-synuclein. Here is the latest research on galectins and alpha-synuclein.

Tauopathies

Tauopathies are neurodegenerative disorders caused due to misfolding and aggregation of the tau protein in neurofibrillary tangles in the brain. Discover the latest research on tauopathies here.

Tau Toxicity in the Synapses

Tau toxicity has been implicated in the emergence of synaptic dysfunction in Alzheimer's disease. Here is the latest research on Tau Toxicity in the Synapses.

T Cell Reactivity to Tau & Alpha-Synuclein in PD

Tau and alpha-synuclein are proteins that form aggregates which characterize various neurodegenerative disorders including Parkinson’s disease. This feed focuses on the reaction of T lymphocytes in response to tau and alpha-synuclein.

Myeloid Cells & Neuroinflammation

Myeloid cells in the CNS are innate immune cells that are essential for brain development and maintenance. Here is the latest research on myeloid cells, including microglia, in neuroinflammation.

Alzheimer's Disease: Neuroimaging

Alzheimer's disease (AD) is a chronic neurodegenerative disease. Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Parkinson's Disease: Alpha-Synuclein

Alpha-synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research.

Tau Toxicity in the Synapses

Tau toxicity has been implicated in the emergence of synaptic dysfunction in Alzheimer's disease. Here is the latest research on Tau Toxicity in the Synapses.

Alpha-Synuclein Aggregation

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Alzheimer's Disease: Abeta

Alzheimer's disease (AD) is a chronic neurodegenerative disease associated with accumulation of amyloid plaques, which are comprised of amyloid beta. Here is the latest research in this field.

Parkinson's Disease (MDS)

Parkinson's Disease is a progressive neurodegenerative disorder characterized by loss of muscle control, including trembling of the limbs and impaired balance. Here is the latest research.

T Cell Reactivity to Tau & Alpha-Synuclein in PD (MDS)

Tau and alpha-synuclein are proteins that form aggregates which characterize various neurodegenerative disorders including Parkinson’s disease. This feed focuses on the reaction of T lymphocytes in response to tau and alpha-synuclein.

Frontotemporal Lobar Degeneration

Frontotemporal lobar degeneration or frontotemporal dementia refers to a group of uncommon disorders that occur as a result of progressive nerve cell loss in the frontal and temporal lobes of the brain. Here is the latest research.

Misfolded Proteins: ND

Protein misfolding is the primary cause of several neurodegenerative disease, including Alzheimer’s and Parkinson’s disease. Here is the latest research.

Synucleinopathies (MDS)

Synucleinopathies are neurodegenerative diseases characterized by accumulation of alpha-synuclein protein aggregates in neurons and glial cells. Discover the latest research on synucleinopathies here.

Galectins & Alpha-Synuclein

Galectins proteins bind to sugar molecules and mediate the cellular response to endocytic vesicles. It is believed that some galectin proteins are involved in microglia activation induced by α-synuclein. Here is the latest research on galectins and alpha-synuclein.

Parkinson's Disease: Alpha-Synuclein (MDS)

Alpha-synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research.

Myeloid Cells And Neuroinflammation

Myeloid cells in the CNS are innate immune cells that are essential for brain development and maintenance. Here is the latest research on myeloid cells, including microglia, in neuroinflammation.

Related Papers

bioRxiv

CSF sTREM2 correlates with CSF tau in advancing Parkinson's disease

bioRxivJune 30, 2019
Edward N. WilsonKatrin I. Andreasson
Molecular Neurodegeneration

Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

Molecular NeurodegenerationJanuary 12, 2019
Marc Suárez-CalvetAlzheimer’s Disease Neuroimaging Initiative
© 2020 Meta ULC. All rights reserved

Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau

Brain : a Journal of Neurology

Feb 18, 2020

Edward N. WilsonKatrin I. Andreasson

PMID: 32065223

DOI: 10.1093/brain/awaa021

Abstract

Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease and affects 1% of the population above 60 years old. Although Parkinson's disease commonly manifests with motor symptoms, a majority of patients with Parkinson's disease subsequently develo...read more

Mentioned in this Paper

Parkinson Disease
Protein Expression
Amyloid beta-Peptides
Neurodegenerative Disorders
Alzheimer's Disease
Participant
Dementia
Population Group
Granulocyte Colony-Stimulating Factor
Receptor
59
1
1

Feeds With Similar Papers

Synucleinopathies

Synucleinopathies are neurodegenerative diseases characterized by accumulation of alpha-synuclein protein aggregates in neurons and glial cells. Discover the latest research on synucleinopathies here.

Tau Aggregation: Genomics

Tau Aggregation is an important characteristic in some neurodegenerative disorders, including Alzheimer’s Disease. Discover the latest research using genomics to understand Tau Aggregation.

Related Papers

bioRxiv

CSF sTREM2 correlates with CSF tau in advancing Parkinson's disease

bioRxivJune 30, 2019
Edward N. WilsonKatrin I. Andreasson
Molecular Neurodegeneration

Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

Molecular NeurodegenerationJanuary 12, 2019
Marc Suárez-CalvetAlzheimer’s Disease Neuroimaging Initiative
Paper Details
References
  • References55
  • Citations
12345...
  • References55
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Download from

Publisher
PubMed
/papers/soluble-trem2-is-elevated-in-parkinsons-disease/32065223