PMID: 16538108Mar 16, 2006Paper

Soluble triggering receptor expressed on myeloid cells (sTREM-1): a new mediator involved in the pathogenesis of peptic ulcer disease

European Journal of Gastroenterology & Hepatology
Vassilios KoussoulasCharalambos Barbatzas

Abstract

Triggering receptor expressed on myeloid cells (TREM-1) is a promoter of cytokine production triggered by microbial components. To investigate the significance of its soluble counterpart, sTREM-1, for the pathogenesis of peptic ulcer disease, sTREM-1 was compared with the proinflammatory mediators and the pathology score of gastritis. Forty patients with dyspepsia were enrolled: 20 with peptic ulcer and 20 controls without any macroscopic abnormalities. All patients were examined by endoscopy; gastric juice was aspirated and biopsy specimens were collected from the antrum and corpus of the stomach. sTREM-1 was estimated by a hand-made enzyme immunoassay. Interleukin-8 was estimated by enzyme-linked immunosorbent assay and lipid peroxidation, indexed by malondialdehyde, by the thiobarbituric assay, after passage through a high-performance liquid chromatography system. The median (+/-SE) of sTREM-1 of controls and patients with ulcer was 3.91+/-0.57 and 44.27+/-241.55 RU, respectively (P=0.006). The median (+/-SE) of interleukin-8 of controls and patients with ulcer was 1802.97+/-122.10 and 2030.66+/-64.44 pg/ml, respectively (P=0.023). sTREM-1 was positively correlated with the density of neutrophil and mononuclear infiltration ...Continue Reading

References

Mar 12, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Evangelos J Giamarellos-BourboulisAthanasios Archimandritis
Nov 6, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Ludovica PiconiAntonio Ceriello
Jan 30, 2004·The New England Journal of Medicine·Sébastien GibotPierre-Edouard Bollaert
Aug 10, 2004·Toxicological Reviews·Barbara E WattJ Allister Vale
Nov 24, 2004·The Journal of Experimental Medicine·Sébastien GibotGilbert C Faure
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sylvia KnappTom van der Poll
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mirjam SchenkChristoph Mueller

❮ Previous
Next ❯

Citations

Nov 18, 2006·Nature Immunology·Julia Klesney-TaitMarco Colonna
Dec 22, 2007·American Journal of Respiratory and Critical Care Medicine·Chao-Chi HoPan-Chyr Yang
Jun 3, 2011·Digestive Diseases and Sciences·Vassilios KoussoulasMark Pimentel
Apr 13, 2007·FEBS Letters·Minou Adib-Conquy, Jean-Marc Cavaillon
Dec 4, 2010·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Ming-Tzer LinChong-Jen Yu
Jun 23, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Yoon Suk JungJae Hee Cheon
Nov 17, 2009·Journal of Critical Care·Mitra BaratiMarzieh Nojomi
Feb 24, 2009·Current Opinion in Immunology·Jill W Ford, Daniel W McVicar
Oct 27, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Enas S Essa, Khaled M A Elzorkany
Jul 11, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Juan Pedro KusanovicSonia S Hassan
Apr 25, 2020·Critical Reviews in Microbiology·Amanda de Oliveira MatosHelioswilton Sales-Campos
Nov 13, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sankar BaruahJulia Klesney-Tait
May 31, 2006·World Journal of Gastroenterology : WJG·Michalis TzivrasAthanasios Archimandritis
Apr 25, 2007·Blood·Philipp HaselmayerMarkus P Radsak
Sep 25, 2019·Cells·Gianfranco NataleFrancesco Fornai
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vanesa Gómez-PiñaEduardo López-Collazo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.