Soluble tumour necrosis factor receptors sTNFR1 and sTNFR2 are produced at sites of inflammation and are markers of arthritis activity in Behçet's disease

Scandinavian Journal of Rheumatology
B TuranP M Villiger

Abstract

We analysed the production of soluble tumour necrosis factor receptors sTNFR1 and sTNFR2 at sites of inflammation and measured their plasma concentrations to evaluate them as biological markers of disease activity. Plasma samples of 35 patients with Behçet's disease (BD) were collected prospectively at monthly intervals and grouped for inactive disease, active BD without arthritis, and active BD with arthritis. sTNFR1 and sTNFR2 concentrations were measured using immunoassays and compared with other biological disease activity parameters. Plasma sTNFR levels were compared to synovial fluid (SF) levels in seven patients. Sixteen tissue samples of mucocutaneous lesions were stained for TNFR2 expression by immunohistochemistry. sTNFR1 and sTNFR2 were found at increased plasma concentrations in active BD, with the highest concentration in active BD with arthritis (p<0.001). Concentrations of both sTNFRs were at least three times higher in SF of arthritic joints than in the corresponding plasma samples (p = 0.025). A change of more than 1 ng/mL of sTNFR2 plasma concentrations correlated with a concordant change in arthritic activity (96% confidence interval). Sensitivity to change was superior to that of sTNFR1, and other biological...Continue Reading

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Citations

Feb 15, 2012·Journal of Inflammation·Kamel HamzaouiAgnès Hamzaoui
Dec 3, 2014·Clinical and Experimental Medicine·Gianluigi MazzoccoliAngelo De Cata
May 18, 2016·Arthritis Research & Therapy·Ayumi NishikawaTsutomu Takeuchi
Apr 5, 2017·Ocular Immunology and Inflammation·Xiaoli LiuGerhild Wildner
Feb 4, 2014·The Journal of Rheumatology·Gulen HatemiHasan Yazici
May 12, 2012·Rheumatology International·Esin Aktas CetinGunnur Deniz
Dec 17, 2009·Ocular Immunology and Inflammation·Srilakshmi M SharmaAndrew D Dick
Nov 6, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ks ShivaprasadSubhankar Chowdhury
Mar 16, 2017·Frontiers in Immunology·Giuseppe LopalcoFlorenzo Iannone
May 1, 2020·International Journal of Molecular Sciences·Tim van der Houwen, Jan van Laar
Jul 7, 2009·Scandinavian Journal of Rheumatology·Y ValleJ F Muñoz-Valle
Apr 10, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Lana M RifkinDebra A Goldstein
Sep 5, 2020·Expert Opinion on Drug Safety·Giuseppe LopalcoFlorenzo Iannone
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Jan 30, 2009·Scandinavian Journal of Rheumatology·S P Raychaudhuri, S K Raychaudhuri

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