Soluble Urokinase Plasminogen Activator Receptor and Outcomes in Patients with Diabetes on Hemodialysis

Clinical Journal of the American Society of Nephrology : CJASN
Christiane DrechslerJochen Reiser

Abstract

Soluble urokinase plasminogen activator receptor is a novel biomarker strongly predictive of cardiovascular outcomes implicated in the pathogenesis of kidney disease. Soluble urokinase plasminogen activator receptor levels, however, correlate with declining kidney function. It is unclear whether soluble urokinase plasminogen activator receptor levels remain associated with outcomes in patients with ESRD. We measured plasma soluble urokinase plasminogen activator receptor levels in 1175 patients (mean age =66±8 years old, 54% men) with type 2 diabetes mellitus on hemodialysis participating in the German Diabetes and Dialysis Study followed for a median of 4 years for outcomes including all-cause death, cardiovascular events, and infection-related mortality. Survival analysis was performed using stepwise Cox proportional hazards models adjusted for potential confounders. Also, adjustments were made for inflammatory markers (C-reactive protein and leukocyte count) and the oxidative stress marker asymmetric dimethyl arginine to investigate potential mediators of the relationship between soluble urokinase plasminogen activator receptor and outcomes. Median soluble urokinase plasminogen activator receptor levels were 10,521 pg/ml (in...Continue Reading

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Citations

Feb 8, 2019·The Journal of Clinical Investigation·Changli WeiJochen Reiser
Feb 25, 2020·European Journal of Preventive Cardiology·Bernd GenserWinfried März
Jun 20, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Óscar Manuel PeiróAlfredo Bardají
Jun 16, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Shengyuan LuoMorgan Erika Grams
Mar 11, 2020·Experimental & Molecular Medicine·Haili LinPeng Xu
May 27, 2020·Endocrine Reviews·Rodolfo J GalindoKatherine R Tuttle
Aug 21, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Li LvMing-Hui Zhao
Jul 24, 2021·European Journal of Preventive Cardiology·Bernd GenserWinfried März
Dec 21, 2021·Frontiers in Immunology·Line Jee Hartmann RasmussenJesper Eugen-Olsen

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