Soluble urokinase receptor and focal segmental glomerulosclerosis

Current Opinion in Nephrology and Hypertension
Jochen ReiserJames Tumlin

Abstract

We discuss recent work on the pathogenetic mechanism of focal segmental glomerulosclerosis (FSGS) and its relationship to soluble urokinase receptor (suPAR). Primary FSGS can affect both children and adults. The disease can recur after kidney transplantation suggesting the involvement of a causative circulating factor. Recent work suggests that approximately two-thirds of FSGS patients have elevated levels of serum suPAR, which confers risk to both native and posttransplant FSGS. Future studies that are geared to understand the clinical implications of high suPAR levels in native FSGS as well as in the pretransplant and posttransplant setting will allow for better patient risk stratification and more targeted treatment options.

References

Jan 15, 1997·European Journal of Biochemistry·G Høyer-HansenK Danø
Jul 3, 1998·International Journal of Cancer. Journal International Du Cancer·H De WitteT Benraad
May 26, 1999·Journal of the National Cancer Institute·R W StephensN Brünner
Mar 23, 2000·The Journal of Clinical Investigation·K V VijayanP F Bray
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anita W RijneveldTom van Der Poll
Dec 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert L StrausbergUNKNOWN Mammalian Gene Collection Program Team
Mar 6, 2004·Scandinavian Journal of Infectious Diseases·Christian OstergaardJesper Eugen-Olsen
Apr 29, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P WittenhagenJ Eugen-Olsen
Oct 11, 2005·Annual Review of Cell and Developmental Biology·M A ArnaoutJ-P Xiong
Dec 18, 2007·Nature Medicine·Changli WeiJochen Reiser
Jul 3, 2009·The New England Journal of Medicine·Laurence H BeckDavid J Salant
Dec 23, 2009·Nature Reviews. Molecular Cell Biology·Harvey W Smith, Chris J Marshall
Feb 13, 2010·Journal of the American Society of Nephrology : JASN·Marco PrunottoGian Marco Ghiggeri
Apr 5, 2011·Biomarker Insights·Abdolreza Sotoodeh JahromiAbdolhossein Madani
Jun 3, 2011·Science Translational Medicine·Alessia FornoniGeorge W Burke
Aug 2, 2011·Nature Medicine·Changli WeiJochen Reiser
Nov 15, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bin ZhangYun Yang
Nov 16, 2011·Biomarker Insights·Anna GustafssonLennart Ljunggren
Dec 23, 2011·The New England Journal of Medicine·Vivette D D'AgatiRonald J Falk

❮ Previous
Next ❯

Citations

Jul 16, 2013·Transplantation·Maarten NaesensBen Sprangers
Nov 10, 2012·Journal of the American Society of Nephrology : JASN·Changli WeiUNKNOWN PodoNet and FSGS CT Study Consortia
Apr 11, 2014·Disease Markers·Crislaine Aparecida da SilvaJuliana Reis Machado
Aug 30, 2014·Advances in Chronic Kidney Disease·Jerry Yee
Mar 8, 2014·Advances in Chronic Kidney Disease·Yasar Caliskan, Krzysztof Kiryluk
Mar 4, 2015·Pediatrics in Review·Tecile Prince Andolino, Jessica Reid-Adam
May 4, 2013·Journal of the American Society of Nephrology : JASN·Ambra Pozzi, Roy Zent
Aug 29, 2019·Frontiers in Pediatrics·Shamitha Thishakya GoonewardenePriyia Pusparajah
Jun 13, 2018·European Journal of Human Genetics : EJHG·Mona Mohamed Watany, Hemat El-Sayed El-Horany
Jun 14, 2019·Disease Markers·Crislaine Aparecida da SilvaJuliana Reis Machado

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.