PMID: 8591123Oct 1, 1995Paper

Solute disequilibrium and multicompartment modeling

Advances in Renal Replacement Therapy
A M KaufmanNathan W Levin

Abstract

Mathematical models that simulate the exchange of solute between multiple body compartments have been used to study the distribution, elimination, and transport of urea, water, electrolytes, and other substances in the dialysis patient. Within a compartment, such substances are assumed to be uniformly distributed while exchange between compartments or with the environment may occur in a number of different ways. Diffusion in response to concentration gradients between, for example, intracellular and extracellular spaces, and convection due to blood flow have been identified as the most important transport mechanisms. Any system with more than one compartment may develop nonuniform solute distribution or solute disequilibrium between compartments. The minimum number of compartments required to model a kinetic process such as urea removal during hemodialysis depends on the accuracy and temporal resolution required, with higher resolution calling for more compartments. A two-compartment model is adequate for most clinical purposes. The physiological meaning or anatomic counterparts of the mathematical compartments remain uncertain as both flow and diffusion transport mechanisms contribute to the disequilibrium. Processes such as a...Continue Reading

Citations

Apr 15, 2005·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Susumu OokawaraKaoru Tabei
Apr 10, 2008·Annals of Biomedical Engineering·E A FernándezM Balzarini
Feb 20, 2010·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Olivera MarsenicMarc Pfister
May 29, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·O D MarsenićO Jovanović
Dec 19, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Manish P PondaThomas H Hostetter
Oct 21, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E JohnssonB Haraldsson
Jan 27, 2005·Artificial Organs·Elmer Andrés FernándezPeter Willshaw

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Nephrology
Thomas A Depner
Journal of the American Society of Nephrology : JASN
S W SmyeE J Will
Seminars in Dialysis
D Schneditz, John T Daugirdas
© 2021 Meta ULC. All rights reserved