Solute removal during continuous renal replacement therapy in critically ill patients: convection versus diffusion.

Critical Care : the Official Journal of the Critical Care Forum
Z RicciPaolo Pietropaoli

Abstract

The best modality, for continuous renal replacement therapy (CRRT) is currently uncertain and it is poorly understood how transport of different solutes, whether convective or diffusive, changes over time. We conducted a prospective cross over study in a cohort of critically ill patients, comparing small (urea and creatinine) and middle (beta2 microglobulin) molecular weight solute clearance, filter lifespan and membrane performance over a period of 72 hours, during 15 continuous veno-venous dialysis (CVVHD) and 15 continuous veno-venous hemofiltration (CVVH)sessions. Both modalities were administered based on a prescription of 35 ml/kg/h and using polyacrylonitrile filters. Median filter lifespan was significantly longer during CVVHD (37 hours, interquartile range (IQR) 19.5 to 72.5) than CVVH (19 hours, IQR 12.5 to 28) (p = 0.03). Median urea time weighted average (TWA) clearances were not significantly different during CVVH (31.6 ml/minute, IQR 23.2 to 38.9) and CVVHD (35.7 ml/minute, IQR 30.1 to 41.5) (p = 0.213). Similar results were found for creatinine: 38.1 ml/minute, IQR 28.5 to 39, and 35.6 ml/minute, IQR 26 to 43 (p = 0.917), respectively. Median beta2m TWA clearance was higher during convective (16.3 ml/minute, IQR ...Continue Reading

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References

Dec 1, 1975·The Journal of Infectious Diseases·G R SiberD H Smith
Jun 26, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A S De VrieseN H Lameire
Jul 12, 2003·Intensive Care Medicine·Shigehiko UchinoRinaldo Bellomo
Feb 26, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Stanislao MorgeraHans-H Neumayer
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rinaldo BellomoUNKNOWN Acute Dialysis Quality Initiative workgroup
Nov 16, 2004·Critical Care Medicine·Alain CariouJean-François Dhainaut
Mar 23, 2005·Critical Care Clinics·Zaccaria Ricci, Claudio Ronco
Jul 1, 2005·Critical Care : the Official Journal of the Critical Care Forum·Zaccaria RicciClaudio Ronco
Jan 31, 2006·Hemodialysis International·Claudio RoncoSudhir K Bowry

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Citations

Jul 21, 2010·Nature Reviews. Nephrology·John R Prowle, Rinaldo Bellomo
Jul 14, 2012·The Journal of Antimicrobial Chemotherapy·Nikolaos MarkouGeorge Baltopoulos
Aug 8, 2012·Critical Care : the Official Journal of the Critical Care Forum·Jan O FriedrichNeill K J Adhikari
Jul 20, 2007·Critical Care : the Official Journal of the Critical Care Forum·Michael Joannidis, Heleen M Oudemans-van Straaten
Jul 29, 2008·Critical Care : the Official Journal of the Critical Care Forum·Jimena del CastilloJose M Bellón
Apr 15, 2011·Critical Care : the Official Journal of the Critical Care Forum·John R ProwleRinaldo Bellomo
Jan 1, 2013·ISRN Nephrology·M E Herrera-GutiérrezG Quesada-García
Feb 3, 2009·Intensive Care Medicine·Graeme Maclaren, Warwick Butt
Jun 11, 2018·Blood Purification·Diego Pomarè MontinClaudio Ronco
Feb 27, 2016·F1000Research·Zaccaria RicciClaudio Ronco
May 12, 2009·Seminars in Dialysis·Jorge Cerdá, Claudio Ronco
Jul 28, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eslam SamahaBernd Jilma
Apr 27, 2011·Seminars in Dialysis·Rolando Claure-Del Granado, Ravindra L Mehta
Jun 22, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Andrew J SlackWilliam Bernal
Sep 1, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Filipe S CardosoUNKNOWN US Acute Liver Failure Study Group
Sep 10, 2014·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Chulananda D GoonasekeraAkash Deep
Sep 14, 2019·Critical Care Medicine·Benjamin SansomRinaldo Bellomo
Oct 19, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Sébastien RedantPatrick M Honore
Sep 3, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Olaf Lebau, Wolfgang Kleinekofort
Aug 28, 2012·The Journal of Trauma and Acute Care Surgery·Manuel E Herrera-GutiérrezRafael Gómez-Villamandos
Dec 17, 2014·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Clare MacEwenChristopher Winearls
Feb 1, 2015·Journal of the Intensive Care Society·Euan BlackUNKNOWN SICS Trainees Audit Share Group
Sep 3, 2018·Blood Purification·Jingxiao ZhangClaudio Ronco
May 11, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Zaccaria RicciClaudio Ronco
Mar 6, 2012·The International Journal of Artificial Organs·Farah N Ali, Jerome C Lane
Sep 30, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jose Angel Sanchez-Izquierdo-RieraSilvia Chacón-Alves
Dec 8, 2019·Intensive Care Medicine Experimental·M OstermannE Hoste
Feb 13, 2016·Nursing in Critical Care·Jody Ede, Andrea Dale
Dec 19, 2018·The Cochrane Database of Systematic Reviews·Alicia Isabel I FayadAgustín Ciapponi
Dec 16, 2020·Archives of Physiology and Biochemistry·Manoj KhokharPraveen Sharma
Jan 13, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sarah N Fernández LafeverMaría J Santiago
Jan 30, 2021·Critical Care : the Official Journal of the Critical Care Forum·Nuttha LumlertgulMarlies Ostermann
Feb 11, 2021·Clinical Kidney Journal·Laura CosmaiGiovambattista Capasso
Mar 13, 2021·Seminars in Dialysis·Claudio Ronco, Thiago Reis

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