Solution conformation of nociceptin

Biochemical and Biophysical Research Communications
S SalvadoriP A Temussi

Abstract

Nociceptin, a novel heptadecapeptide, interacts with ORL1 a G protein-coupled receptor whose sequence is closely related to that of the kappa opioid receptor but has no opioid activity. We have investigated the conformational preferences of Nociceptin also in comparison to Dynorphin A. The N-terminal part of Nociceptin has the same conformational preferences of the message of endogenous opioids but the C-terminal part of the sequence is more flexible than the corresponding address of Dynorphin A. [Tyr1]-Nociceptin, while retaining nociceptive activity, has also an opioid activity comparable to that of enkephalins.

References

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Citations

Sep 19, 2000·British Journal of Pharmacology·M HoA T McKnight
Dec 1, 2004·Journal of Peptide Science : an Official Publication of the European Peptide Society·Lidia KlaudelJacek Wójcik
Aug 7, 2008·Journal of Peptide Science : an Official Publication of the European Peptide Society·Bruno VincentPascal Demange
Oct 10, 2002·Journal of Peptide Science : an Official Publication of the European Peptide Society·Pietro AmodeoPiero A Temussi
Aug 12, 1999·Journal of Peptide Science : an Official Publication of the European Peptide Society·R SpadacciniP A Temussi
May 17, 2000·FEBS Letters·P AmodeoT Tancredi
Jul 16, 2010·Biopolymers·E Podstawka-ProniewiczL M Proniewicz
Feb 19, 2000·Biopolymers·O CrescenziP A Temussi
Jul 21, 2011·Organic & Biomolecular Chemistry·Gemma ArsequellGregorio Valencia
Nov 15, 2002·Journal of Medicinal Chemistry·Chongwu ZhangDonald J Kyle

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