PMID: 9531420Apr 8, 1998Paper

Solution conformational analysis of sodium complexed [Gly6]- and [Gly9]-antamanide analogs

The Journal of Peptide Research : Official Journal of the American Peptide Society
P AmodeoT Tancredi

Abstract

To investigate the conformational flexibility of metal-complexed cyclodecapeptides, we synthesized and studied two antamanide analogs, in which the phenylalanine residue in position 6 or 9 of the sequence was substituted by Gly. Previous conformational studies on antamanide suggested that these backbone regions are affected by conformational variation. The NMR conformational study showed a high degree of flexibility for the two analogs. With sodium ions, on the other hand, [Gly9]-antamanide was able to form a fairly stable equimolar complex, whereas [Gly6]-antamanide showed a conformational heterogeneity, with one prevailing conformer. For the [Gly9]-antamanide analog, the whole NMR data, combined with extensive theoretical calculations, were consistent with the presence of 1) two beta-turns of type I, centered on Gly9-Phe10 and Ala4-Phe5, respectively; 2) a central cavity with a six-carbonyl oxygen cage, optimal for a Na+ hexacoordination; 3) strongly H-bonded amide protons for residues 1 and 6, both involved in the formation of the two type I beta-turns, which, however, exhibited some fluctuations during the molecular dynamics simulations. For the [Gly6]-antamanide-Na+ complex the prevailing conformer was consistent with a mo...Continue Reading

References

Jun 9, 1972·Biochemical and Biophysical Research Communications·T WielandW Burgermeister
Dec 16, 1983·Biochemical and Biophysical Research Communications·M RanceK Wüthrich
Apr 1, 1986·Journal of Computational Chemistry·Scott J WeinerDavid A Case

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Citations

Sep 4, 2003·Journal of Peptide Science : an Official Publication of the European Peptide Society·John S Davies
Apr 27, 2001·Chemistry : a European Journal·G SavianoM Saviano
Nov 25, 2000·Peptides·L NegriR Lattanzi
Mar 18, 1999·Progress in Neurobiology·L H LazarusS Salvadori
Aug 15, 2002·Archives of Biochemistry and Biophysics·Maria HinajeBhupinder Khambay

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