Solution NMR studies of peptide-lipid interactions in model membranes

Molecular Membrane Biology
Lena Mäler

Abstract

Many important processes in life take place in or around the cell membranes. Lipids have different properties regarding their membrane-forming capacities, their mobility, shape, size and surface charge, and all of these factors influence the way that proteins and peptides interact with the membrane. In order for us to correctly understand these interactions, we need to be able to study all aspects of the interplay between lipids and peptides and proteins. Solution-state NMR offers a somewhat unique possibility to investigate structure, dynamics and location of proteins and peptides in bilayers. This review focuses on solution NMR as a tool for investigating peptide-lipid interaction, and special attention is given to the various membrane mimetics that are used to model the membrane. Examples from the field of cell-penetrating peptides and their lipid interactions will be given. The importance of studying lipid and peptide dynamics, which reflect on the effect that peptides have on bilayers, is highlighted, and in this respect, also the need for realistic membrane models.

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Citations

Nov 10, 2012·Advanced Drug Delivery Reviews·Lena Mäler
Dec 17, 2014·Biochimica Et Biophysica Acta·Andrea BodorLena Mäler
Dec 15, 2015·Magnetic Resonance in Chemistry : MRC·Jobst LiebauLena Mäler
Sep 6, 2015·Biochimica Et Biophysica Acta·Johannes BjörneråsLena Mäler
Aug 6, 2015·Biophysical Journal·Jobst LiebauLena Mäler
Jan 27, 2015·Journal of Biomolecular NMR·Julia MisiewiczAnne S Ulrich
Jun 1, 2016·Protein Expression and Purification·Andrea N NaranjoAnne Skaja Robinson
Jun 19, 2016·Biochimica Et Biophysica Acta·Jobst LiebauLena Mäler
Nov 9, 2016·International Journal of Biological Macromolecules·Joyeeta Mukherjee, Munishwar Nath Gupta
Feb 9, 2017·Chemical Reviews·Ilia G Denisov, Stephen G Sligar
Jul 15, 2017·The Journal of Physical Chemistry. B·Jobst Liebau, Lena Mäler
Mar 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Shu ZhouPia Ädelroth
Aug 1, 2018·Expert Opinion on Biological Therapy·Walter MandalitiMaurizio Paci
Jun 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Niels GeudensJosé C Martins
Jan 11, 2013·The Journal of Physical Chemistry. B·Weihua YeLena Mäler

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