Solution phase parallel synthesis and evaluation of MAPK inhibitory activities of close structural analogues of a Ras pathway modulator

Bioorganic & Medicinal Chemistry Letters
Yingchun LuSanjay R Menon

Abstract

A solution phase parallel synthesis approach was undertaken to rapidly explore the structure-activity relationship of an inhibitor of the Ras/Raf protein interaction identified from a small molecule compound library. Evaluation of the MAPK pathway signaling inhibitory activity of the synthesized analogues as well as their antiproliferative activity and ability to inhibit soft agar growth were performed.

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Citations

Feb 11, 2014·Bioorganic & Medicinal Chemistry·Wiktor SzymanskiRyszard Ostaszewski
Jun 16, 2014·Nature Chemical Biology·Jochen SpiegelHerbert Waldmann
Nov 21, 2007·Expert Opinion on Therapeutic Targets·Vladimir KhazakErica A Golemis
Oct 17, 2015·Angewandte Chemie·Philipp M CrommHerbert Waldmann
Jan 8, 2017·Cancer Research·Adam B KeetonGary A Piazza
Nov 5, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·Imran KhanJohn P O'Bryan

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