Solution structure of a C-terminal coiled-coil domain from bovine IF(1): the inhibitor protein of F(1) ATPase

Journal of Molecular Biology
D J Gordon-SmithD Neuhaus

Abstract

Bovine IF(1) is a basic, 84 amino acid residue protein that inhibits the hydrolytic action of the F(1)F(0) ATP synthase in mitochondria under anaerobic conditions. Its oligomerization state is dependent on pH. At a pH value below 6.5 it forms an active dimer. At higher pH values, two dimers associate to form an inactive tetramer. Here, we present the solution structure of a C-terminal fragment of IF(1) (44-84) containing all five of the histidine residues present in the sequence. Most unusually, the molecule forms an anti-parallel coiled-coil in which three of the five histidine residues occupy key positions at the dimer interface.

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Citations

Jul 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·John V BasonJohn E Walker
Apr 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·John V BasonJohn E Walker
Aug 26, 2015·Journal of Bioenergetics and Biomembranes·Cindy ChimeoAdriana Muhlia-Almazan
Feb 9, 2017·Cellular and Molecular Life Sciences : CMLS·Pau B Esparza-MoltóJosé M Cuezva
Dec 4, 2003·Journal of Molecular Biology·David L ZoeteweyRobert S Hodges
Jan 31, 2018·FEBS Letters·Anežka KahancováAndrea Dlasková
Oct 31, 2001·FEBS Letters·L Domínguez-RamírezM Tuena de Gómez-Puyou
Sep 12, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pau B Esparza-MoltóJosé M Cuezva
Aug 19, 2003·Nature Structural Biology·Elena CabezónJohn E Walker
Dec 13, 2005·Journal of Bioenergetics and Biomembranes·Stefania ContessiGiovanna Lippe
May 17, 2011·The Journal of Biological Chemistry·Daniela De los Rios CastilloOscar Flores-Herrera
Aug 21, 2002·The Journal of Biological Chemistry·Elena CabezonJohn E Walker
Nov 13, 2004·The Biochemical Journal·Jonathan R Gledhill, John E Walker
Aug 23, 2011·Protein Science : a Publication of the Protein Society·Jorge Ramos, Themis Lazaridis
May 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Vytaute BoreikaiteJohn E Walker
Mar 8, 2019·Scientific Reports·Venkata S MandalaMei Hong
Sep 30, 2018·Journal of Bioenergetics and Biomembranes·Francisco Mendoza-HoffmannJosé J García-Trejo
Mar 1, 2021·Protein Science : a Publication of the Protein Society·Nikolaus M Loening, Elisar Barbar

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