PMID: 9187659Jun 1, 1997Paper

Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand

Nature Structural Biology
K YamasakiY Ota

Abstract

We have determined the NMR structure of a ligand-binding domain of the granulocyte colony-stimulating factor (G-CSF) receptor, containing the highly conserved WSxWS motif. The domain consists of seven beta-strands with the fibronectin type III-like topology seen in several cytokine receptors. Comparisons between the spectra of the 15N-labelled domain with and without G-CSF indicate that the major ligand-recognition site is on the FG loop just upstream of the WSxWS sequence, and not on the BC loop which is mainly used in the growth hormone system. The WSxWS residues are suggested to contribute to ligand-recognition and to the protein architecture of the G-CSF receptor.

References

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Citations

Jun 21, 2005·Veterinary Immunology and Immunopathology·Eri KitamiyaYasuyuki Momoi
Sep 30, 2010·Metabolic Syndrome and Related Disorders·Meiju SaukkoOlavi Ukkola
May 2, 1998·The EMBO Journal·J BravoE Y Jones
Apr 21, 1999·Protein Science : a Publication of the Protein Society·T KernebeckJ Grötzinger
Nov 21, 2002·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kosuke Morikawa
Sep 24, 1999·Biological Chemistry·J GrötzingerS Rose-John
Apr 9, 2013·Molecular Cell·Falk F R BuettnerHans Bakker
Mar 17, 2006·The Journal of Biological Chemistry·Frank PeelmanJan Tavernier
Feb 22, 2000·The Journal of Biological Chemistry·C OlivierH Gascan
Oct 15, 2003·The Journal of Biological Chemistry·Andreas SchwantnerJoachim Grötzinger
Nov 8, 2002·Biochimica Et Biophysica Acta·Joachim Grötzinger

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