PMID: 9437429Jan 23, 1998Paper

Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPase

Nature Structural Biology
J GitschierW J Fairbrother

Abstract

Menkes disease is an X-linked disorder in copper transport that results in death during early childhood. The solution structures of both apo and Ag(I)-bound forms of the fourth metal-binding domain (mbd4) from the Menkes copper-transporting ATPase have been solved. The 72-residue mbd4 has a ferredoxin-like beta alpha beta beta alpha beta fold. Structural differences between the two forms are limited to the metal-binding loop, which is disordered in the apo structure but well ordered in the Ag(I)-bound structure. Ag(I) binds in a linear bicoordinate manner to the two Cys residues of the conserved GMTCxxC motif; Cu(I) likely coordinates in a similar manner. Menkes mbd4 is thus the first bicoordinate copper-binding protein to be characterized structurally. Sequence comparisons with other heavy-metal-binding domains reveal a conserved hydrophobic core and metal-binding motif.

References

Jun 1, 1992·Protein Science : a Publication of the Protein Society·S G HybertsG Wagner
Apr 1, 1992·European Journal of Biochemistry·L Sahlman, B H Jonsson
Jan 1, 1991·Advances in Protein Chemistry·E T Adman
Jan 1, 1989·Proteins·P CarterJ A Wells
Feb 1, 1989·Trends in Biochemical Sciences·S SilverT K Misra
Dec 5, 1995·Biochemistry·S Lutsenko, J H Kaplan
Oct 29, 1993·Biochemical and Biophysical Research Communications·L Sahlman, E G Skärfstad
Jan 1, 1993·Nature Genetics·J F MercerD Siemieniak
Jan 1, 1995·Annual Review of Nutrition·C D Vulpe, S Packman
Mar 19, 1996·Biochemistry·N E JacobsenW J Fairbrother
Feb 1, 1996·Journal of Molecular Graphics·R KoradiK Wüthrich
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y YamaguchiJ D Gitlin
Dec 3, 1996·Biochemistry·M A StarovasnikW J Fairbrother
Dec 1, 1996·Journal of Biomolecular NMR·R A LaskowskiJ M Thornton
Apr 4, 1997·The Journal of Biological Chemistry·S J LinV C Culotta
Apr 4, 1997·The Journal of Biological Chemistry·L W KlompJ D Gitlin
Nov 5, 1997·Science·R A PufahlT V O'Halloran
Apr 1, 1986·Journal of Computational Chemistry·Scott J WeinerDavid A Case

❮ Previous
Next ❯

Citations

Jul 13, 2002·Biopolymers·Tara M DeSilvaStanley J Opella
Aug 14, 2001·Biochemical and Biophysical Research Communications·B FanB P Rosen
Mar 8, 2007·Journal of Structural and Functional Genomics·Christian KöhlerHartmut Oschkinat
Oct 24, 2003·Journal of Structural Biology·Christopher E JonesCharles T Dameron
Jan 19, 2000·Trends in Biochemical Sciences·M D HarrisonC T Dameron
Jun 1, 2002·Current Opinion in Chemical Biology·Sergi Puig, Dennis J Thiele
Jun 1, 2002·Current Opinion in Chemical Biology·Stanley J OpellaGianluigi Veglia
Apr 1, 2000·Current Opinion in Chemical Biology·A C Rosenzweig, T V O'Halloran
Jul 10, 2007·Biochemistry·Bryan T Op't Holt, Kenneth M Merz
Oct 15, 2009·Chemical Reviews·Amie K Boal, Amy C Rosenzweig
Jul 24, 2010·The Journal of Biological Chemistry·Lone BaekgaardMichael G Palmgren
Jul 5, 2007·The Journal of Biological Chemistry·Matthew H SazinskyAmy C Rosenzweig
Apr 4, 2008·The Journal of Biological Chemistry·Steen V PetersenJan J Enghild
Jul 27, 2010·Applied and Environmental Microbiology·Aurelio Moraleda-MuñozJosé Muñoz-Dorado
Apr 2, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Oleg Y Dmitriev
Jun 8, 2001·Annual Review of Biochemistry·D L Huffman, T V O'Halloran
Jun 11, 2004·Annual Review of Nutrition·Vadim N GladyshevDolph L Hatfield
Jul 26, 2005·Bioscience, Biotechnology, and Biochemistry·Yoshito SasakiTomonobu Kusano
Mar 31, 2006·Proceedings of the National Academy of Sciences of the United States of America·David AchilaDavid L Huffman
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·I HamzaJ D Gitlin
May 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lucia BanciMurugendra Vanarotti
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z WeissmanD Kornitzer
Jan 16, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·José M ArgüelloManuel González-Guerrero
Jan 17, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Chloe Singleton, Nick E Le Brun
Nov 4, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Mathias LübbenMarc Solioz
Jan 25, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·N A VeldhuisJ Camakaris
Mar 25, 2010·Cellular and Molecular Life Sciences : CMLS·Lucia BanciSimone Ciofi-Baffoni
Oct 24, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Amanda N BarrySvetlana Lutsenko
Oct 3, 2012·Biological Chemistry·Pontus GourdonPoul Nissen
Nov 24, 2004·Proteins·Yuan Qi, Nick V Grishin
Jul 10, 2003·The Plant Journal : for Cell and Molecular Biology·Rebecca F MillsLorraine E Williams
Jan 6, 2004·Proteins·Alexei SavchenkoRong-guang Zhang

❮ Previous
Next ❯

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