Solution structure of the SWIRM domain of human histone demethylase LSD1

Structure
Naoya TochioShigeyuki Yokoyama

Abstract

SWIRM is an evolutionarily conserved domain involved in several chromatin-modifying complexes. Recently, the LSD1 protein, which bears a SWIRM domain, was found to be a demethylase for Lys4-methylated histone H3. Here, we report a solution structure of the SWIRM domain of human LSD1. It forms a compact fold composed of 6 alpha helices, in which a 20 amino acid long helix (alpha4) is surrounded by 5 other short helices. The SWIRM domain structure could be divided into the N-terminal part (alpha1-alpha3) and the C-terminal part (alpha4-alpha6), which are connected to each other by a salt bridge. While the N-terminal part forms a SWIRM-specific structure, the C-terminal part adopts a helix-turn-helix (HTH)-related fold. We discuss a model in which the SWIRM domain acts as an anchor site for a histone tail.

References

Nov 1, 1995·Journal of Biomolecular NMR·F DelaglioA Bax
May 23, 1996·Nature·R W HooftE E Abola
Feb 1, 1996·Journal of Molecular Graphics·R KoradiK Wüthrich
Dec 1, 1996·Journal of Biomolecular NMR·R A LaskowskiJ M Thornton
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·P F KosaP B Sigler
Jan 1, 1997·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·L E Kay
Nov 21, 1997·Journal of Molecular Biology·P GüntertK Wüthrich
Sep 22, 1999·Molecular and Cellular Biology·A EberharterJ L Workman
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·A YouS L Schreiber
May 10, 2001·Current Opinion in Cell Biology·J C Rice, C D Allis
Jun 8, 2001·Annual Review of Biochemistry·S Y RothC D Allis
Aug 3, 2001·Nature·S J NielsenT Kouzarides
Aug 11, 2001·Science·T Jenuwein, C D Allis
Jan 5, 2002·The Journal of Biological Chemistry·David E SternerShelley L Berger
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mohamed-Ali HakimiRamin Shiekhattar
Jul 12, 2002·Cell·Andrew J BannisterTony Kouzarides
Sep 28, 2002·Nature·Helena Santos-RosaTony Kouzarides
Dec 21, 2002·The Journal of Biological Chemistry·Mohamed-Ali HakimiRamin Shiekhattar
Feb 13, 2003·Current Opinion in Structural Biology·Christopher W Akey, Karolin Luger
Nov 25, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alexandra Lusser, James T Kadonaga
Dec 3, 2003·Journal of Structural and Functional Genomics·JunGoo Jee, Peter Güntert
Mar 17, 2004·Biochimica Et Biophysica Acta·Alejandra Loyola, Genevieve Almouzni

❮ Previous
Next ❯

Citations

Sep 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yong ChenMing Lei
Oct 22, 2008·Molecular and Cellular Biology·Armin M GamperRobert G Roeder
Jan 24, 2007·FEBS Letters·Satoshi OhnishiShigeyuki Yokoyama
May 21, 2011·Bioorganic & Medicinal Chemistry·Brian LohseRasmus P Clausen
May 4, 2010·Analytical Biochemistry·Akane KawamuraChristopher Schofield
Mar 22, 2007·Mutation Research·Xiaodong Cheng, Xing Zhang
Dec 13, 2007·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
Jun 20, 2008·Protein Science : a Publication of the Protein Society·Satoshi OhnishiShigeyuki Yokoyama
Jul 25, 2015·Fly·Andreana HolowatyjLori A Pile
Aug 28, 2012·Comparative and Functional Genomics·Yan GaoKeqiang Wu
Mar 20, 2015·Biopolymers·Jonathan M BurgDewey G McCafferty
May 21, 2015·Medicinal Research Reviews·Yi-Chao ZhengHong-Min Liu
Mar 25, 2015·Journal of Structural and Functional Genomics·Naoya TochioShigeyuki Yokoyama
May 21, 2011·Molecular Cell·Peter MulliganAnders M Näär
Apr 13, 2007·Journal of Molecular Biology·Misao YoneyamaShigeyuki Yokoyama
Sep 23, 2006·The Journal of Biological Chemistry·Estelle NicolasRamin Shiekhattar
Nov 14, 2015·EMBO Reports·Emilia DimitrovaRobert J Klose
Dec 5, 2019·Nucleic Acids Research·Julie M J LepesantLuisa Di Stefano
Mar 10, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Hideaki Niwa, Takashi Umehara
Jun 24, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sarder ArifuzzamanRabeya Khatun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.