Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).

Nature Structural & Molecular Biology
Sebastian EustermannDavid Neuhaus

Abstract

Addition of poly(ADP-ribose) (PAR) is an important post-translational modification in higher eukaryotes. Several DNA repair and checkpoint proteins possess specific PAR-binding zinc-finger (PBZ) modules critical for function. Here, we present solution structures of the two PBZ modules of aprataxin and PNK-like factor (APLF), revealing a novel type of zinc finger. By combining in vivo PAR-binding data with NMR interaction data using PAR fragments, we propose a structural basis for PBZ-PAR recognition.

References

Aug 24, 1999·The Biochemical Journal·D D'AmoursG G Poirier
Aug 10, 2000·Nature·D M Scolnick, T D Halazonetis
Oct 4, 2000·The Journal of Biological Chemistry·J M PleschkeF R Althaus
Feb 26, 2004·Nature Structural & Molecular Biology·Brian P HudsonPeter E Wright
May 20, 2005·The EMBO Journal·Georgios I KarrasAndreas G Ladurner
Sep 6, 2005·Genes & Development·Mi Young KimW Lee Kraus
Jul 11, 2006·Nature Reviews. Molecular Cell Biology·Valérie SchreiberGilbert de Murcia
Mar 14, 2007·Molecular and Cellular Biology·Natasha IlesKeith W Caldecott
May 14, 2008·Molecular and Cellular Biology·Stuart L RultenKeith W Caldecott
Dec 2, 2008·Nature Structural & Molecular Biology·Marianna Teplova, Dinshaw J Patel
Aug 15, 2009·Nature Structural & Molecular Biology·Gyula TiminszkyAndreas G Ladurner

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Citations

Apr 25, 2012·Journal of Biomolecular NMR·Pierre BarraudFrédéric H-T Allain
Dec 27, 2012·Molecular Aspects of Medicine·Jana KrietschJean-Philippe Gagné
Mar 6, 2013·Molecular Aspects of Medicine·Tobias KarlbergHerwig Schüler
Jun 21, 2012·Nature Reviews. Molecular Cell Biology·Bryan A Gibson, W Lee Kraus
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Guang-Yao LiC Anne Koch
Jun 7, 2012·Nucleic Acids Research·Jean-Philippe GagnéGuy G Poirier
Mar 3, 2011·Genes & Development·Sophie E Polo, Stephen P Jackson
Apr 7, 2015·Molekuliarnaia biologiia·M M KutuzovO I Lavrik
Jun 30, 2012·Analytical Biochemistry·Edwin S TanTimothy J Mitchison
Jul 7, 2012·Trends in Biochemical Sciences·Thomas KalischValérie Schreiber
Oct 28, 2011·Current Opinion in Structural Biology·Mark Bycroft
Dec 18, 2015·Nucleic Acids Research·Federico Teloni, Matthias Altmeyer
Sep 25, 2015·Nucleic Acids Research·Feng ZhangXiaochun Yu
May 29, 2013·The FEBS Journal·Eva BarkauskaiteGyula Timinszky
Nov 28, 2012·The EMBO Journal·Gabrielle J GrundyKeith W Caldecott
Sep 21, 2010·International Journal of Cancer. Journal International Du Cancer·Aswin Mangerich, Alexander Bürkle
Jan 22, 2013·Current Opinion in Structural Biology·Marie-France Langelier, John M Pascal
Jan 15, 2013·Current Opinion in Genetics & Development·Matthias Altmeyer, Jiri Lukas
Mar 22, 2015·DNA Repair·Robert E London
Jan 8, 2011·Molecular Cell·Pawan Vinod MehrotraIvan Ahel
Mar 12, 2013·Structure·Alexandra H ForstBernhard Lüscher
Jan 31, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Stuart L Rulten, Gabrielle J Grundy
May 18, 2017·Nature Reviews. Molecular Cell Biology·Howard H Y ChangMichael R Lieber
Nov 4, 2017·Critical Reviews in Biochemistry and Molecular Biology·Kerryanne CrawfordIvan Ahel
Sep 3, 2016·Journal of Cell Science·Alasdair R GunnNicholas D Lakin
Dec 17, 2017·The Journal of Biological Chemistry·Nicholas R PannunzioMichael R Lieber
Oct 13, 2011·British Journal of Cancer·M Javle, N J Curtin
Feb 8, 2020·Genes & Development·Kameron Azarm, Susan Smith
Oct 30, 2016·The Journal of Biological Chemistry·Jay OzaShridar Ganesan
Apr 30, 2017·Nucleic Acids Research·R Daniel AceytunoJ N Mark Glover
Sep 11, 2010·Chemical Communications : Chem Comm·Jennifer L FurmanIndraneel Ghosh
Sep 1, 2017·Nucleic Acids Research·Chao LiuXiaochun Yu
Jan 1, 2012·Biomolecules·Roko ZajaIvan Ahel

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