Solvent-dependent on/off valving using selectively permeable barriers in paper microfluidics

Lab on a Chip
G Ij SalentijnE Verpoorte

Abstract

We report on a new way to control solvent flows in paper microfluidic devices, based on the local patterning of paper with alkyl ketene dimer (AKD) to form barriers with selective permeability for different solvents. Production of the devices is a two-step process. In the first step, AKD-treated paper (hydrophobic) is exposed to oxygen plasma for re-hydrophilization. 3D-printed masks are employed to shield certain areas of this paper to preserve well-defined hydrophobic patterns. In the second step, concentrated AKD in hexane is selectively deposited onto already hydrophobic regions of the paper to locally increase the degree of hydrophobicity. Hydrophilic areas formed in the previous oxygen plasma step are protected from AKD by wetting them with water first to prevent the AKD hexane solution from entering them (hydrophilic exclusion). Characterization of the patterns after both steps shows that reproducible patterns are obtained with linear dependence on the dimensions of the 3D-printed masks. This two-step methodology leads to differential hydrophobicity on the paper: (i) hydrophilic regions, (ii) low-load AKD gates, and (iii) high-load AKD walls. The gates are impermeable to water, yet can be penetrated by most alcohol/water...Continue Reading

References

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Citations

Dec 13, 2016·Analytical Chemistry·Yuanyuan YangCharles S Henry
Sep 25, 2017·Lab on a Chip·Gert Ij SalentijnElisabeth Verpoorte
Jan 13, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Yuhi Shimada, Takashi Kaneta
Oct 29, 2020·Scientific Reports·Arthur ZargaryanSam H Au
Jun 15, 2021·Chemical Reviews·Eka NovianaCharles S Henry
Aug 7, 2021·RSC Advances·Nurul Nadiah HamidonElisabeth Verpoorte
Nov 20, 2018·Analytical Chemistry·G Ij SalentijnE Verpoorte

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