Solvent Effects: Syntheses of 3,3-Difluorooxindoles and 3-Fluorooxindoles from Hydrazonoindolin-2-one by Selectfluor

The Journal of Organic Chemistry
Qiong YangZhen-Yu Tang

Abstract

Efficient syntheses of 3,3-difluorooxindoles and 3-fluorooxindoles via fluorination of hydrazonoindolin-2-one with Selectfluor are reported. Under different solvent conditions, this method produced 3,3-difluorooxindoles and 3-fluorooxindoles selectively. The broad substrate scope and mild reaction conditions make this transformation a valuable method in drug discovery and development.

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Jul 21, 2005·Journal of the American Chemical Society·Yoshitaka HamashimaMikiko Sodeoka
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Mar 16, 2017·The Journal of Organic Chemistry·Ling-Chao YuXingang Zhang

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Citations

Jul 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nadiia V PikunYuriy G Shermolovich
Apr 13, 2019·The Journal of Organic Chemistry·Jianbo ZhaoXinfeng Ren
Dec 23, 2021·Organic & Biomolecular Chemistry·Yong-Liang LiuYa Li

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