Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

Polymers
Víctor Santos-RosalesCarlos A García-González

Abstract

The regenerative medicine field is seeking novel strategies for the production of synthetic scaffolds that are able to promote the in vivo regeneration of a fully functional tissue. The choices of the scaffold formulation and the manufacturing method are crucial to determine the rate of success of the graft for the intended tissue regeneration process. On one hand, the incorporation of bioactive compounds such as growth factors and drugs in the scaffolds can efficiently guide and promote the spreading, differentiation, growth, and proliferation of cells as well as alleviate post-surgical complications such as foreign body responses and infections. On the other hand, the manufacturing method will determine the feasible morphological properties of the scaffolds and, in certain cases, it can compromise their biocompatibility. In the case of medicated scaffolds, the manufacturing method has also a key effect in the incorporation yield and retained activity of the loaded bioactive agents. In this work, solvent-free methods for scaffolds production, i.e., technological approaches leading to the processing of the porous material with no use of solvents, are presented as advantageous solutions for the processing of medicated scaffolds ...Continue Reading

References

Oct 27, 1998·Journal of Biomedical Materials Research·L D HarrisD J Mooney
Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·M H SheridanD J Mooney
Mar 20, 2001·Journal of Biomedical Materials Research·E A BotchweyC T Laurencin
Nov 2, 2001·Nature Biotechnology·T P RichardsonD J Mooney
Jul 19, 2002·Journal of Biomedical Materials Research·F A MasperoE Wintermantel
Sep 1, 2004·International Journal of Pharmaceutics·S Freiberg, X X Zhu
Dec 1, 2004·The Journal of Bone and Joint Surgery. British Volume·M BordenC T Laurencin
Jun 21, 2005·Journal of Materials Science. Materials in Medicine·J C LorrisonD J Wood
Jul 23, 2005·Journal of Biomedical Materials Research. Part a·L M MathieuJ-A E Månson
Jul 1, 2006·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·L HaoR A Harris
Apr 28, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Rebecca Louise SimpsonMun Wai Lee
Apr 30, 2008·Journal of Biomedical Materials Research. Part a·Caren E Petrie AroninEdward A Botchwey
Mar 18, 2009·Journal of Biomedical Materials Research. Part a·Xuetao ShiDong-An Wang
May 12, 2009·International Journal of Pharmaceutics·Xuetao ShiDong-An Wang
May 28, 2009·Biotechnology and Bioengineering·Mark W Tibbitt, Kristi S Anseth
Jul 14, 2009·Biomacromolecules·Andrea BarbettaMariella Dentini
Jul 21, 2009·Acta Biomaterialia·Szilvia EosolyLisa Looney
Nov 7, 2009·Biomacromolecules·Andrea BarbettaMariella Dentini
Jul 28, 2012·Tissue Engineering. Part C, Methods·Su Hee KimSoo Hyun Kim
Nov 2, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ju Hyeong JeonMichael S Detamore
Dec 12, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Cristina ColosiMariella Dentini
Apr 23, 2013·Small·Roland H StaffDaniel Crespy
Oct 8, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Manjari BhamidipatiMichael S Detamore
Sep 3, 2014·Journal of Biomaterials Science. Polymer Edition·Joshua MintonAzizeh-Mitra Yousefi
Dec 6, 2014·Annals of Biomedical Engineering·Christopher T Johnson, Andrés J García

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Citations

Nov 17, 2020·International Journal of Biological Macromolecules·Kamel R ShoueirMaged El-Kemary
Jun 18, 2021·International Journal of Pharmaceutics·Víctor Santos-RosalesCarlos A García-González
Jul 14, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·María J Sánchez-FernándezSander C G Leeuwenburgh
Dec 2, 2020·Biomacromolecules·Víctor Santos-RosalesAmeya Rege

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