Solvent-free mixed micellar mobile phases: An advanced green chemistry approach for reversed-phase HPLC determination of some antihypertensive drugs.

Journal of Separation Science
Adel Ehab IbrahimFathalla Belal

Abstract

Minimizing the amount of organic solvents without loss in chromatographic performance has been an important step toward greening analytical methodologies. Mobile-phase composition is the key for maintaining separation efficiency in liquid chromatography while decreasing the procedure hazardousness. If sodium dodecyl sulfate is mixed with Brij-35 in the mobile phase, they could be used as a green alternative for using organic modifiers. In this research, the effect of changing the relative amounts of both surfactants was studied on the chromatographic performance and separation efficiency of ten antihypertensive drugs belonging to different categories. The use of surfactants has many advantages including low cost and toxicity, safe environmental disposal, unique selectivity besides high solubilization capabilities. The optimum separation was maintained using a mobile phase (0.01 M Brij-35, 0.08 M sodium dodecyl sulfate and 0.01 M sodium dihydrogen phosphate/pH 5) on reversed-phase C18 core-shell column at flow rate 1.5 mL/min and temperature 30°C. The method was successfully applied for the determination of the drugs in various marketed dosage forms. International Conference of Harmonization guidelines were followed to validate ...Continue Reading

References

May 26, 2005·Journal of Separation Science·Najma MemonM Y Khuhawer
Apr 14, 2015·Journal of Separation Science·Ester Peris-GarcíaMaría Celia García-Alvarez-Coque
May 3, 2019·Analytica Chimica Acta·Faustino TarongoyJoselito P Quirino
Feb 7, 2020·Nature Reviews. Nephrology·Katherine T MillsJiang He

❮ Previous
Next ❯

Citations

Mar 30, 2021·Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science·Ibraam E MikhailAdel Ehab Ibrahim
Jun 19, 2021·Analytical and Bioanalytical Chemistry·Adel Ehab IbrahimHeba Mohamed El-Sayed

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Analytical and Bioanalytical Chemistry
Ester Peris-GarcíaMaría José Ruiz-Ángel
Journal of Separation Science
Ester Peris-GarcíaM C García-Álvarez-Coque
Analytical and Bioanalytical Chemistry
Adel Ehab IbrahimHeba Mohamed El-Sayed
© 2022 Meta ULC. All rights reserved