Solvent Tolerance in Bacteria: Fulfilling the Promise of the Biotech Era?

Trends in Biotechnology
Hadiastri KusumawardhaniJohannes H de Winde

Abstract

The challenge of sustainably producing highly valuable chemical compounds requires specialized microbial cell factories because many of these compounds can be toxic to microbial hosts. Therefore, solvent-tolerant bacteria are promising production hosts because of their intrinsic tolerance towards these compounds. Recent studies have helped to elucidate the molecular mechanisms involved in solvent tolerance. Advances in synthetic biological tools will enable further development of streamlined solvent-tolerant production hosts and the transfer of solvent-tolerant traits to established industrial strains. In this review, we outline challenges and opportunities to implement solvent tolerance in bacteria as a desired trait for industrial biotechnology.

Citations

Aug 14, 2020·Applied Microbiology and Biotechnology·Anna WeimerChristoph Wittmann
Jul 1, 2020·Frontiers in Bioengineering and Biotechnology·Sebastian KöbbingNick Wierckx
Jun 15, 2019·Microbial Biotechnology·Linde F C KampersVitor A P Martins Dos Santos
May 10, 2020·Nature Communications·Qiang DingXiulai Chen
Sep 27, 2020·Biotechnology Journal·Tobias SchwanemannBenedikt Wynands
Jan 21, 2021·Trends in Biotechnology·Julia JodlbauerFlorian Rudroff
Jan 8, 2021·Applied Microbiology and Biotechnology·Barbora BranskaPetra Patakova
Mar 7, 2021·Applied and Environmental Microbiology·Hadiastri KusumawardhaniJohannes H de Winde
Jul 6, 2021·Essays in Biochemistry·Nora Lisa BitzenhoferAnita Loeschcke
Jul 25, 2021·Biotechnology and Bioengineering·Guangjie LiangLiming Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.