PMID: 482Nov 1, 1975

Solvolysis of a substituted imidazoline, mazindol

Journal of Pharmaceutical Sciences
H V MauldingJ P Nazareno


Hydrolysis of mazindol to form 2-(2-aminoethyl)-3-(p-chlorophenyl)-3-hydroxyphthalimidine was followed spectro-photometrically in aqueous solutions at temperatures between 37 and 70degree, pH values up to 7.6, and an ionic strength of 0.2. The effects of acetate, formate, and phosphate buffers as well as ionic strength on the observed rate constants were investigated. An interesting nonlinear dependency of the kobs with buffer concentration was noted. The velocity constants declined with increasing hydrogen-ion concentration; the log k-pH profile and rate law are given along with other relevant data.


Jul 1, 1976·Journal of Pharmaceutical Sciences·F W Goodhart, M L Eichman

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