Somatic cell hybrids between totipotent mouse teratocarcinoma and rat hepatoma cells

Journal of Cellular Physiology
G Litwack, C M Croce


We have produced somatic cell hybrids between totipotent mouse teratocarcinoma cells and rat hepatoma cells. These hybrids were tested for the expression of liver specific functions expressed in the hepatoma cell parent and for their ability to differentiate when injected into nude mice. The results of this study indicate that hybrid cell clones do not resemble either of the parental cells, since they do not produce albumin and tyrosine aminotransferase that are expressed in the rat hepatoma parent, and are incapable of forming either teratocarcinomas or hepatomas when injected in experimental animals.


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Related Concepts

Liver Carcinoma
Neoplasm Transplantation
Tyrosine Aminotransferase
House mice
Hepatoma, Novikoff
Cell Differentiation Process
Mice, Nude

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