Somatic cell hybrids between totipotent mouse teratocarcinoma and rat hepatoma cells

Journal of Cellular Physiology
G Litwack, C M Croce

Abstract

We have produced somatic cell hybrids between totipotent mouse teratocarcinoma cells and rat hepatoma cells. These hybrids were tested for the expression of liver specific functions expressed in the hepatoma cell parent and for their ability to differentiate when injected into nude mice. The results of this study indicate that hybrid cell clones do not resemble either of the parental cells, since they do not produce albumin and tyrosine aminotransferase that are expressed in the rat hepatoma parent, and are incapable of forming either teratocarcinomas or hepatomas when injected in experimental animals.

References

Jul 1, 1982·Somatic Cell Genetics·L K Wray, H E Sutton
Jan 1, 1983·Folia Biologica·J Huppert
Apr 1, 1989·Nurse Education Today·M A Andrusyszyn
Jan 1, 1982·Differentiation; Research in Biological Diversity·D DubouleK Illmensee
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·J W ShayM A Clark
Jan 1, 1983·Somatic Cell Genetics·L K Wray, H K Jaeckle

Citations

Sep 1, 1976·Cell·R A Miller, F H Ruddle
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·K IllmenseeC M Croce
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·K Illmensee, C M Croce
May 17, 1977·Biochemistry·J A GoidlG Litwack
Oct 1, 1977·Archives of Biochemistry and Biophysics·L G Parchman, G Litwack
Apr 29, 1972·Lancet·M Seabright
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·C M CroceH Koprowski
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·C M CroceH Eagle
Oct 1, 1967·Analytical Biochemistry·A WeinsteinG Litwack
Nov 1, 1974·Nature·K G OrkwiszewskiC M Croce

Related Concepts

Totipotent
Alb
Liver Carcinoma
Neoplasm Transplantation
Tyrosine Aminotransferase
House mice
Hepatoma, Novikoff
Cell Differentiation Process
Hybrids
Mice, Nude

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