Somatic characteristics and cardiovascular risk factors in growth hormone deficiency: a randomized, double-blind, placebo-controlled study of the effect of treatment with recombinant human growth hormone

American Journal of Human Biology : the Official Journal of the Human Biology Council
W BellR Mullen

Abstract

The purpose of the present study was to identify the effect of treatment with recombinant human growth hormone (rhGH) on seven somatic characteristics and eight clinical cardiovascular risk factors. Twenty-seven male and 24 female patients between the ages of 21 and 60 years were examined. The investigation was a double-blind, placebo-controlled study of 12 months duration. Patients were assigned randomly to treatment (T) and placebo (P) groups. In the first 6 months group T received rhGH and group P placebo. In the second 6 months both groups received rhGH. Complete data were available for 23 males and 20 females. Increments were calculated between 6 months -BL (increment 1) and 12-6 months (increment 2) in both T and P groups. Apart from the somatotype, data were analysed with a 2 x 2 mixed analysis of variance (ANOVA) using treatment (rhGH and placebo) and time (increments 1 and 2). Somatotype data were analysed using a 2 x 3 multivariate ANOVA. Three significant interactions were identified in males: waist circumference (P = 0.006), trunk fat (P = 0.0001), and conicity index (P = 0.001). The only significant interaction in females was trunk fat (P = 0.006). In general, treatment and placebo groups responded differently by t...Continue Reading

References

Jul 1, 1995·Archives of Disease in Childhood·J V FreemanM A Preece
Oct 1, 1994·Endocrine Reviews·L SaccàS Fazio
Oct 1, 1994·Physiological Reviews·A H Kissebah, G R Krakower
Jan 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M K LewisI Fogelman
Jan 1, 1994·Clinical Endocrinology·T RosénB A Bengtsson
Mar 1, 1993·The American Journal of Clinical Nutrition·K van der KooyC J Bakker
Jun 6, 1998·BMJ : British Medical Journal·D PounderY Orihara
Jun 24, 2000·Annals of the New York Academy of Sciences·W BellM F Scanlon
Aug 9, 2001·Endocrine Reviews·W M DrakeS M Shalet
Sep 5, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·Simon R.P. WilliamsEleri Jones
Apr 22, 2003·American Journal of Human Biology : the Official Journal of the Human Biology Council·Mark DanielMichael J Marfell-Jones
Jul 1, 1996·Multivariate Behavioral Research·N Cliff
Jan 1, 1996·American Journal of Human Biology : the Official Journal of the Human Biology Council·William H MuellerP Sim Chandler
Jan 1, 1998·American Journal of Human Biology : the Official Journal of the Human Biology Council·Peter T KatzmarzykClaude Bouchard
Jan 1, 1997·American Journal of Human Biology : the Official Journal of the Human Biology Council·Robert M MalinaClaude Bouchard

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Citations

Nov 16, 2012·European Journal of Endocrinology·Valentina GascoGianluca Aimaretti
Apr 18, 2008·Der Internist·M Faust, C J Strasburger
May 7, 2011·Neuroepidemiology·Paolo RagoneseGiovanni Savettieri
Sep 14, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Paolo RagoneseGiovanni Savettieri

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