Somatic DNA mutation analysis in targeted therapy of solid tumours

Translational Pediatrics
Bing YuRonald J Trent

Abstract

Cancer is a disease of the genome with diverse aetiologies including the accumulation of acquired mutations throughout the genome. There has been a flood of knowledge improving our understanding of the biology and molecular genetics of melanoma, lung and colorectal cancer since the genomics era started. Translation of this knowledge into a better understanding of cell proliferation, survival and apoptosis has produced a paradigm shift in medical oncology enabling gene-based cancer treatment (called personalised or precision medicine). Somatic mutation analysis is crucial for a genomics approach since it can identify driver mutations-the "Achilles' heel" of cancer, and support clinical decision-making through targeted therapy. Nevertheless, the applications of somatic DNA testing in cancer face many challenges such as obtaining comprehensive coverage of the cancer genome with limited DNA being available, and delivering an accurate report in a timely fashion without false-negative and false-positive results. Further advances in DNA technologies and bioinformatics will overcome these issues and maximise opportunities for targeted therapy. Somatic mutation analysis will then become an integral part of cancer management for all mali...Continue Reading

Citations

Jun 14, 2016·Human Vaccines & Immunotherapeutics·R Servín-BlancoK Manoutcharian
Jan 20, 2017·Molecular Diagnosis & Therapy·Florence MaugerJörg Tost
Oct 15, 2019·Frontiers in Oncology·Alistair Rice, Armando Del Rio Hernandez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Australian Family Physician
Siaw-Teng Liaw
Asian Pacific Journal of Cancer Prevention : APJCP
Khalid Khalaf Alharbi
Journal of Thoracic Disease
Morgan R DavidsonBelinda E Clarke
International Journal of Computational Biology and Drug Design
Pan DuJack Y Yang
© 2021 Meta ULC. All rights reserved