Somatic extracts of Marshallagia marshalli downregulate the Th2 associated immune responses in ovalbumin-induced airway inflammation in BALB/c mice

Parasites & Vectors
Sima Parande ShirvanAlireza Haghparast

Abstract

Recently the role of gastrointestinal nematodes in modulating the immune responses in inflammatory and immune-mediated conditions such as allergy and autoimmune diseases has been introduced. This is mainly due to the suppressive effects of somatic and excretory secretory (ES) products of nematodes on the immune responses. In this study, we evaluated the immunomodulatory potentials of somatic products of Marshallagia marshalli, a gastrointestinal nematodes of sheep, to suppress the immune-mediated responses in a murine model of allergic airway inflammation. BALB/c mice were intraperitoneally (IP) sensitized with ovalbumin (OVA)/Alum and then challenged with 1% OVA. Somatic products of M. marshalli were administered during each sensitization. The effects of somatic products on development of allergic airway inflammation were evaluated by analyzing inflammatory cells recruitment, histopathological changes, cytokines production (IL-4, IL-13, IL-10, TGF-β) and serum antibody titers (IgG1, IgG2a). Somatic products of M. marshalli were able to suppress the induction of allergic airway inflammation in mice. Modulation of Th2 type responses (IL-4, IL-13, IgG1) via upregulations of IL-10 and TGF-β production was observed after injection ...Continue Reading

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Citations

Jul 23, 2020·Dose-response : a Publication of International Hormesis Society·Mingming ZhangXuesong Xu
Oct 16, 2019·Frontiers in Immunology·Sandra CoronadoLuis Caraballo
Jun 7, 2021·Journal of Exposure Science & Environmental Epidemiology·Rachael E RushBrett J Green
Jun 29, 2021·Frontiers in Pharmacology·Tingting ChenQiang Liu

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Methods Mentioned

BETA
bronchoalveolar
lavage
enzyme linked immunosorbent assay
ELISA

Software Mentioned

Prism

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