PMID: 8946200Nov 1, 1996Paper

Somatic genetic events linked to the Apc locus in intestinal adenomas of the Min mouse

Genes, Chromosomes & Cancer
C Luongo, W F Dove

Abstract

We have found previously that all spontaneous intestinal adenomas from Apc+/ApcMin mice lose the wild type Apc marker on two genetic backgrounds. On the (AKR x B6)F1 background, this event involves loss of the entire homolog of mouse chromosome 18 carrying Apc+. This chromosome carries both the Mcc and Dcc genes, which are homologs of genes that have been implicated in human colorectal cancer. To determine whether the loss of alleles of Mcc and/or Dcc is necessary for the formation of intestinal adenomas, subchromosomal somatic events were induced by gamma-irradiation. The observed spectrum of intrachromosomal somatic genetic losses rules out a requirement for loss of heterozygosity at either locus during adenoma formation. Subchromosomal allelic losses linked to Apc+ occur spontaneously on other genetic backgrounds. In the majority of these events, the Apc+ allele itself was somatically lost, as judged by the wild type marker at the Min site. However, on the [M. musculus castaneous (CAST) x B6-Min]F1 and (129/Sv x B6-Min)F1 backgrounds, spontaneous adenomas were observed in which the wild type marker at the Min site was retained. Further analysis will be required to determine whether these exceptions involve intra-Apc mutation...Continue Reading

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y MiyoshiG Petersen
Sep 17, 1992·Nature·S M PowellK W Kinzler
Aug 9, 1991·Science·K W KinzlerD McKechnie
Aug 13, 1987·Nature·E SolomonS H Rider
Jan 1, 1988·British Journal of Cancer·L H Breimer
Apr 21, 1995·Cell·P W LairdR Jaenisch
Jan 1, 1994·Cold Spring Harbor Symposia on Quantitative Biology·W F DoveR L Gardner
Nov 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K R JohnsonM T Davisson
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·W F DietrichE S Lander
Jan 1, 1993·Human Mutation·H Nagase, Y Nakamura
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R W WisemanP Söderkvist
Mar 1, 1996·Molecular and Cellular Biology·G M D'AbacoA W Burgess
Apr 1, 1951·Proceedings of the Society for Experimental Biology and Medicine·H L ABRAMS

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Citations

Aug 19, 2007·Oncogene·L N KwongW F Dove
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W F DoveA R Shoemaker
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·A R ShoemakerW F Dove
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yasuhiro YamadaRudolf Jaenisch
Jul 11, 1998·Experimental Lung Research·K A Gould, W F Dove
Jan 12, 2011·International Journal of Radiation Biology·Michele EllenderRoger Cox
Apr 28, 2006·International Journal of Radiation Biology·M EllenderR Cox
Sep 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Ayumi NojiriTetsuya Tsukamoto
May 26, 2001·Genomics·O A IakoubovaD B West
Jun 1, 2016·Frontiers in Genetics·Adrienne L WatsonScott C Fahrenkrug
Feb 27, 2016·PloS One·Christopher D ZahmRichard B Halberg
May 31, 2001·Nature Genetics·K L RudolphR A DePinho
Oct 4, 2003·Blood·P Louise ColettaAlexander F Markham
Jun 13, 2000·Oncogene·A R ShoemakerW F Dove
Apr 2, 2005·Journal of Radiation Research·Mieko Okamoto, Hiromichi Yonekawa
May 20, 2011·Health Physics·Y ShimadaS Kakinuma
Sep 1, 2017·Environmental and Molecular Mutagenesis·Anne GraupnerAnn Karin Olsen
Aug 19, 1999·Genes, Chromosomes & Cancer·C W van der Houven van OordtR Fodde
Sep 8, 2017·Frontiers in Oncology·Kyle M SchachtschneiderLawrence B Schook
Jul 5, 2019·International Journal of Radiation Oncology, Biology, Physics·Shubhankar SumanKamal Datta

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