PMID: 25731028Mar 4, 2015Paper

Somatic genome variations in vascular tissues and peripheral blood leukocytes in patients with atherosclerosis

Genetika
A A SleptsovV P Puzyrev

Abstract

The first data on the existence of multiple genomic rearrangements, such as copy number variation (CNV) and copy neutral loss of heterozygosity, in vascular tissues and peripheral blood leukocytes from patients with atherosclerosis, are presented. Compared to internal mammary arteries and peripheral blood leukocytes, right coronary arteries in the atherosclerotic plaque area presented with a higher CNV length and number of genes located in their vicinity. In each of the patients, 6-16% of CNVs were common to the three types of tissues examined. Therefore, most of the copy number variations in the tissues affected by atherosclerosis (from 68 to 91% in each of the patients) were of somatic origin. The gains in 3p21.31 (CACNA2D2), 7q32.1 (FLNC), 19p13.3 (C19orf29, PIP5K1C), and 21q22.3 (COL6A1) were detected in vascular tissues but not in peripheral blood leukocytes. Moreover, the gain in 7p15.2 (SKAP2), detected in the patients with atherosclerosis, did not overlap with any CNV regions currently reported in The Database of Genomic Variants. The loss of heterozygosity in 12 out of 13 chromosomal regions was copy neutral and covered tumor suppressor genes (SFRP1, CEBPD, RB1CC1, DIRAS3, TUSC3, and ZDHHC2).

References

Jul 15, 1990·Cancer Genetics and Cytogenetics·R VanniS Licheri
Aug 5, 1996·Biochemical and Biophysical Research Communications·J HatzistamouD A Spandidos
Jan 19, 2000·Trends in Genetics : TIG·K D PruittD R Maglott
Jan 12, 2001·Molecular Cell Biology Research Communications : MCBRC·G A FlourisD A Spandidos
Mar 21, 2001·Atherosclerosis·L MatturriJ Milei
Mar 5, 2004·European Journal of Human Genetics : EJHG·Sergey NazarenkoAlbert Schinzel
Mar 24, 2005·Journal of Cellular and Molecular Medicine·D A ArvanitisD A Spandidos
Jun 20, 2007·Circulation·Rebecca L Pollex, Robert A Hegele
Jun 24, 2008·Human Mutation·Arkadiusz PiotrowskiJan P Dumanski
Dec 6, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jin Soo ChoiHyoung Kyun Rha
Feb 10, 2009·Nature Genetics·UNKNOWN Myocardial Infarction Genetics ConsortiumDavid Altshuler
Mar 20, 2009·Human Molecular Genetics·Nisha LimayeMiikka Vikkula
Sep 3, 2009·Journal of Medical Genetics·R Happle
Nov 11, 2009·Cardiovascular Research·José J FusterVicente Andrés
Jan 26, 2010·Human Genetics·Bruce GottliebMark A Trifiro
Jan 29, 2010·Blood·Christine O'KeefeJaroslaw P Maciejewski
Apr 3, 2010·Nature·UNKNOWN Wellcome Trust Case Control ConsortiumPeter Donnelly
May 19, 2010·Nature Reviews. Genetics·Evan E EichlerJoseph H Nadeau
Aug 3, 2011·Molecular Carcinogenesis·Sraboni MitraChinmay K Panda
Jan 21, 2012·The Korean Journal of Thoracic and Cardiovascular Surgery·Jong Hui SuhYoung-Pil Wang
May 9, 2012·Nature Genetics·Cathy C LaurieBruce S Weir
May 9, 2012·Nature Genetics·Kevin B JacobsStephen J Chanock
May 15, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Katerina VrzalikovaPaul Gerard Murray
Sep 15, 2012·Journal of Cell Science·Francis J AlenghatKenneth D Swanson
Oct 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Maeve O'HuallachainMichael P Snyder
Nov 20, 2012·The Journal of Biological Chemistry·Shintaro ShimamuraMasamitsu Tanaka
Jun 6, 2013·Bioinformatics·Jindan ZhouKenneth E Rudd
Jun 20, 2013·Postgraduate Medical Journal·Lars Anders ForsbergJan Piotr Dumanski
Jul 31, 2013·Database : the Journal of Biological Databases and Curation·Qingyan LiXianhua Dai

❮ Previous
Next ❯

Citations

Jul 6, 2015·Progress in Neurobiology·Marta Pulido-SalgadoJosep Saura
Mar 9, 2017·Journal of Cellular and Molecular Medicine·Xinshuang YuJuan Du

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.