PMID: 6966073Jan 1, 1980Paper

Somatic hybrids between a high NK-sensitive lymphoid (YACIR) and several low sensitive sarcoma or L-cell-derived mouse lines exhibit low sensitivity

Somatic Cell Genetics
L Ahrlund-RichterG Masucci

Abstract

Mouse somatic cell hybrids between a high NK-sensitive lymphoma line (YACIR) and various sarcoma or L-cell-derived cell lines (all weakly sensitive) all exhibited low NK sensitivity. This was not due to a general resistance to cell-mediated lysis, since these mouse hybrids could be killed by in vitro-sensitized specific T cells. Alloantigens are usually codominantly expressed in somatic cell hybrids, whereas differentiation-related markers are usually suppressed. Because NK sensitivity was found to be suppressed, in contrast to the expression of alloantigens and tumor-associated antigens, we suggest that the target structure may be either a differentiation-related antigen or a differentiation-related "membrane property."

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Citations

Mar 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·V A Lavrovskiĭ, R M Ibragimov
Oct 1, 1982·Molecular Immunology·E KleinF Vánky
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J C RoderD Kozbor
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D P DubeyR Sager
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L VodinelichM Greaves
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Mar 15, 1981·International Journal of Cancer. Journal International Du Cancer·F VánkyE Klein
Oct 15, 1981·International Journal of Cancer. Journal International Du Cancer·G YogeeswaranR M Welsh

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