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Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers

Proceedings of the National Academy of Sciences of the United States of America

Nov 25, 1998

M DiazMartin F Flajnik

PMID: 9826702

Abstract

The new antigen receptor (NAR) gene in the nurse shark diversifies extensively by somatic hypermutation. It is not known, however, whether NAR somatic hypermutation generates the primary repertoire (like in the sheep) or rather is used in antigen-driven immune responses. To address this...read more

Mentioned in this Paper

Immune Response
Structure of Germinal Center of Lymph Node
CDR1 gene
Peripheral Blood
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Receptors, Antigen
Transcription, Genetic
Ginglymostoma cirratum
CDR1 protein, human
Homologous Sequences, Amino Acid
33
Paper Details
References
  • References32
  • Citations52
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  • References32
  • Citations52
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Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers

Proceedings of the National Academy of Sciences of the United States of America

Nov 25, 1998

M DiazMartin F Flajnik

PMID: 9826702

DOI:

Abstract

The new antigen receptor (NAR) gene in the nurse shark diversifies extensively by somatic hypermutation. It is not known, however, whether NAR somatic hypermutation generates the primary repertoire (like in the sheep) or rather is used in antigen-driven immune responses. To address this...read more

Mentioned in this Paper

Immune Response
Structure of Germinal Center of Lymph Node
CDR1 gene
Peripheral Blood
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Receptors, Antigen
Transcription, Genetic
Ginglymostoma cirratum
CDR1 protein, human
Homologous Sequences, Amino Acid
33

Feeds With Similar Papers

Germinal Centers

Geminal centres are located within secondary lymphoid organs including the spleen where B cell proliferation, differentiation, and antibody class-switching occurs. Here is the latest research.

Immunoglobulin Class Switching

Immunoglobulin class switching from igm to igg and iga is central to immunity against viruses and requires the activation of b cells by t cells via cd154 and cytokines. Discover the latest research on immunoglobulin class switching here.

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Paper Details
References
  • References32
  • Citations52
1234
  • References32
  • Citations52
12345...

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