Somatic hypermutations in the VH segment of immunoglobulin genes of CD5-positive diffuse large B-cell lymphomas

Japanese Journal of Cancer Research : Gann
M KumeM Seto

Abstract

De novo CD5-positive (CD5+) diffuse large B-cell lymphoma (DLBL) has recently been identified as constituting a homogeneous subgroup with distinct clinicopathologic and genotypic characteristics, but its origin remains to be elucidated. Previous studies by sequence analysis of the variable region of the immunoglobulin heavy chain (VH) have shown that CD5+ B-cell malignancies such as mantle cell lymphoma (MCL) and B-cell chronic lymphocytic leukemia (B-CLL) cells represent pre-germinal center (pre-GC) stage B cells in contrast with the post-GC stage of most DLBLs, which show somatic hypermutations in VH genes. In the present study, we investigated the VH sequence of de novo CD5+ DLBL to clarify whether CD5+ DLBL represents the pre-GC stage, as do other CD5+ B-cell malignancies, or the post-GC stage, as is typical of DLBL. All eight cases (four CD5+ DLBL and four CD5-negative (CD5-) DLBL) examined by us showed somatic hypermutations in the VH segment and two of the CD5- DLBL cases showed intra-clonal diversity, suggesting that CD5+ DLBLs were derived from the same maturation stage as CD5- DLBL, but were distinct from the other indolent CD5+ B-cell lymphomas of B-CLL and MCL. These data suggest that de novo CD5+ DLBLs do not merel...Continue Reading

References

Jan 1, 1991·Leukemia Research·R KüppersK Rajewsky
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jan 1, 1989·Advances in Immunology·T J Kipps
Jun 1, 1985·The Journal of Experimental Medicine·K HayakawaL A Herzenberg
Sep 1, 1993·DNA and Cell Biology·F H SarkarJ D Crissman

❮ Previous
Next ❯

Citations

Mar 11, 2008·Annals of Hematology·Giovanni CarulliMario Petrini
Jun 25, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D EnnishiK Hatake
Jul 11, 2000·British Journal of Haematology·T InabaM Nakagawa
Oct 29, 2003·Cytometry. Part B, Clinical Cytometry·Sara A MonaghanCharles L Goolsby
Nov 18, 2008·The American Journal of Surgical Pathology·Jun WangQin Huang
Oct 5, 2006·American Journal of Hematology·Prashant JaniHong Chang
Jan 23, 1999·Current Opinion in Hematology·P M LydyardP Y Youinou
Sep 12, 2020·American Journal of Clinical Pathology·Ayumi FujimotoRitsuro Suzuki

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.