Oct 24, 2014

SomaticSignatures: Inferring Mutational Signatures from Single Nucleotide Variants

BioRxiv : the Preprint Server for Biology
Julian S GehringWolfgang Huber

Abstract

Mutational signatures are patterns in the occurrence of somatic single nucleotide variants (SNVs) that can reflect underlying mutational processes. The SomaticSignatures package provides flexible, interoperable, and easy-to-use tools that identify such signatures in cancer sequencing data. It facilitates large-scale, cross-dataset estimation of mutational signatures, implements existing methods for pattern decomposition, supports extension through user-defined methods and integrates with Bioconductor workflows. The R package SomaticSignatures is available as part of the Bioconductor project ([R Core Team, 2014][1]; [Gentleman et al ., 2004][2]). Its documentation provides additional details on the methodology and demonstrates applications to biological datasets. [1]: #ref-9 [2]: #ref-6

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Mentioned in this Paper

Patterns
Sequencing
Nucleotides
Cancer Care
Core
Single Nucleotide Polymorphism
Silo (Dataset)
MHV surface projection glycoprotein

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