Somatolactin selectively regulates proliferation and morphogenesis of neural-crest derived pigment cells in medaka

Proceedings of the National Academy of Sciences of the United States of America
Shoji FukamachiAkihiro Shima

Abstract

Species-specific colors and patterns on animal body surfaces are determined primarily by neural-crest-derived pigment cells in the skin (chromatophores). However, even closely related species display widely differing patterns. These contrasting aspects of chromatophores (i.e., the fixed developmental control within species and extreme diversity among species) seem to be a curious and suitable subject for understanding evolution and diversity of organisms. Here we identify a gene responsible for medaka "color interfere" mutants by positional cloning. These mutants do not show any obvious morphological and physiological defects other than defects in chromatophore proliferation and morphogenesis. The mutation has been identified as an 11-base deletion in somatolactin, which causes truncation 91 aa upstream of the C terminus of the protein's 230 aa. Somatolactin transcription changed dramatically during morphological body color adaptation to different backgrounds. This genetic evidence explains somatolactin function. Studying this mutant will provide further insights into the development and regulation of chromatophores and clues for reassessing other functions of somatolactin suggested in other fish.

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Citations

Dec 13, 2005·Anatomy and Embryology·Ingibjörg Eir EinarsdóttirBjörn Thrandur Björnsson
Jun 20, 2013·International Journal of Biological Sciences·Mingyou LiYunhan Hong
Aug 25, 2010·Annual Review of Genetics·Hiroyuki Takeda, Atsuko Shimada
May 3, 2008·General and Comparative Endocrinology·Yoshio Takei
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Jul 11, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Yuichi OzakiKohei Yamauchi
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Feb 21, 2006·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Maximiliano Martín CánepaPaula Gabriela Vissio
Jun 5, 2008·American Journal of Physiology. Endocrinology and Metabolism·Quan JiangAnderson O L Wong
Jun 5, 2008·American Journal of Physiology. Endocrinology and Metabolism·Quan JiangAnderson O L Wong
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May 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Victor M LewisDavid M Parichy

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