PMID: 9434053Jan 1, 1997Paper

Somatopause and adiposity

Hormone Research
J O JørgensenJ S Christiansen

Abstract

Mobilization of lipids is the pivotal action of growth hormone (GH) in both children and adults. The temporal association between declining GH levels and accumulation of body fat with ageing is, therefore, interesting although the cause-effect relationship remains unknown. Recent cross-sectional data suggest that both stimulated and spontaneous GH release is predominantly predicted by the amount of abdominal fat in both men and women. The same study also shows that ageing is associated with an increased metabolic clearance rate and apparent distribution volume, both of which correlate positively with fat mass and negatively with age. Furthermore, the acute lipolytic response to a GH bolus is somewhat lower in older adults (and in women). It is, therefore, proposed that changes in life style and dietary habits, perhaps together with an age-determined reduced lipolytic responsiveness to GH, initiates fat accumulation. The increased fat mass, in turn, inhibits the release and promotes the clearance of GH thus establishing a vicious circle.

Citations

Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S Y Nam, P E Lobie
Nov 17, 2010·American Journal of Human Biology : the Official Journal of the Human Biology Council·Miryoung LeeEllen W Demerath
Aug 3, 1999·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·E ArvatE Ghigo
Feb 18, 2004·Journal of Endocrinological Investigation·F LanfrancoE Arvat

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