Somatosensation in OA: exploring the relationships of pain sensitization, vibratory perception and spontaneous pain

BMC Musculoskeletal Disorders
Anisha B DuaNajia Shakoor

Abstract

Pain in osteoarthritis (OA) remains poorly understood. Different types of somatosensory alterations exist in OA including hyperesthesia and increased sensitivity to painful stimuli as well as those of decreased sensitivity to cutaneous stimuli including vibratory perception threshold. The relationship between these different somatosensory measures has not been previously evaluated in OA. In this observational study, we evaluated relationships between vibratory perception (VPT), pressure pain detection thresholds (PPT), allodynia and subjective pain in knee OA. Forty-two persons with moderate to severe knee OA and 12 controls without OA were evaluated. VPT was measured using a biothesiometer. Allodynia was measured by application of a 60 g Von Frey monofilament repeatedly to predetermined sites. PPTs were measured using a pressure algometer. Increased vibratory acuity was associated with lower PPTs and presence of allodynia. Allodynia was more common in OA than controls (54.8% vs 16.6%, p = 0.024 in the ipsilateral knee, and 42.9% vs 0%, p = 0.005 in the contralateral knee). OA participants with allodynia had lower PPTs than those without allodynia. In those with OA, spontaneous knee pain was associated with lower PPTs and with ...Continue Reading

References

Jan 7, 1998·Arthritis and Rheumatism·Y C PaiL Sharma
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Feb 12, 2004·Arthritis and Rheumatism·Thorsten GieseckeDaniel J Clauw
Aug 12, 2005·Current Opinion in Rheumatology·David T Felson
Dec 31, 2005·Arthritis and Rheumatism·Béla SzebenyiJohn R Kirwan
Jun 15, 2007·Arthritis Research & Therapy·Andy Dray, Simon J Read
Jan 1, 2008·Arthritis and Rheumatism·Najia ShakoorJoel A Block
Jun 28, 2008·Pain·John D Loeser, Rolf-Detlef Treede
Sep 2, 2008·Arthritis and Rheumatism·Najia ShakoorJoel A Block
Apr 27, 2010·Pain·Lars Arendt-NielsenThomas Graven-Nielsen
Nov 29, 2011·Rheumatology·Vikki WyldePaul Dieppe
Jul 25, 2012·The Journal of Pain : Official Journal of the American Pain Society·Gary J Bennett
Dec 20, 2013·Annals of the Rheumatic Diseases·Tuhina NeogiUNKNOWN Multicenter Osteoarthritis (MOST) Study
Apr 5, 2014·European Journal of Pain : EJP·E LluchJ Van Oosterwijck
Mar 10, 2015·Osteoarthritis and Cartilage·C FingletonC Doody
Aug 30, 2017·Osteoarthritis and Cartilage·L A DevezaD J Hunter

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Citations

Sep 2, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Robert SuchtingHyochol Ahn
Sep 29, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jonathan RankinLisa C Carlesso

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