Somatosensory perception and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from rheumatoid arthritis

European Journal of Pain : EJP
A S LefflerP Hansson

Abstract

The purpose was to investigate the influence of ongoing pain from an inflammatory nociceptive pain with two different disease durations on somatosensory functions and the effect of heterotopic noxious conditioning stimulation (HNCS) on 'diffuse noxious inhibitory controls' (DNIC) related mechanisms. Eleven patients with rheumatoid arthritis of a short duration (<1 year) (RA1), and 10 patients with rheumatoid arthritis of longer duration (>5 years) (RA5) as well as 21 age- and sex-matched healthy controls participated. Pressure pain sensitivity, low threshold mechanoreceptive function and thermal sensitivity, including thermal pain, were assessed over a painful and inflamed joint as well as in a pain-free area, i.e. the right thigh before HNCS (cold-pressor test) and repeated at the thigh only during and following HNCS. In RA1 and RA5 allodynia to pressure was seen over the joint (p<0.02 and p<0.001 respectively) in conjunction with hypoaesthesia to light touch (p<0.02) and hyperaesthesia to innocuous cold (p<0.05) in RA5. At the thigh, allodynia to pressure was found in RA5 (p<0.002). During HNCS, the sensitivity to pressure pain decreased in patients and controls alike (p<0.001). In conclusion, over an inflamed joint allodynia...Continue Reading

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References

Jun 1, 1990·Acta Neurologica Scandinavica·D ClausB Neundörfer
Aug 1, 1990·Brain : a Journal of Neurology·T De BrouckerD Le Bars
Feb 19, 1985·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H L Fields, M M Heinricher
Aug 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·P HanssonP Marchettini
Sep 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·A Ekblom, P Hansson
Jan 1, 1987·The Journal of Hand Surgery·J Bell-Krotoski, E Tomancik
Nov 1, 1985·Journal of Neurophysiology·H G Schaible, R F Schmidt
Oct 28, 1972·British Medical Journal·E C Huskisson, F D Hart
Mar 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·D Kirk
Nov 19, 1965·Science·R Melzack, P D Wall
Mar 1, 1970·Journal of Neurophysiology·B N Christensen, E R Perl
Jun 1, 1995·British Journal of Rheumatology·S E HewlettJ R Kirwan
Dec 20, 1994·Journal of the Neurological Sciences·D Meh, M Denislic
Jan 1, 1995·British Journal of Rheumatology·J A HogewegP J Helders
Jan 1, 1994·Somatosensory & Motor Research·A V ApkarianS J Bolanowski
Oct 1, 1993·Pain·Hans-Georg Schaible, Blair D Grubb
Jan 1, 1996·Journal of the Neurological Sciences·S WatanabeM Shimojo
Sep 26, 1997·The Clinical Journal of Pain·S Lautenbacher, G B Rollman
Feb 20, 1999·Zeitschrift für Rheumatologie·S Mense

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Citations

Aug 30, 2003·Current Pain and Headache Reports·Lars Arendt-Nielsen, Thomas Graven-Nielsen
Nov 6, 2009·Current Pain and Headache Reports·Patrick B Wood
Oct 31, 2012·Current Pain and Headache Reports·David A Walsh, Daniel F McWilliams
Jul 20, 2002·Current Rheumatology Reports·Thomas Graven-Nielsen, Lars Arendt-Nielsen
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·J Amir HendianiTerry McNearney
Mar 11, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G CruccuT S Jensen
Nov 3, 2010·The Journal of Clinical Investigation·Michael H OssipovFrank Porreca
Jun 19, 2007·Arthritis Research & Therapy·Bruce L KiddTheresa Wodehouse
May 6, 2009·Arthritis Research & Therapy·Robert R EdwardsGayle G Page
Jan 1, 2012·Scientifica·Michael H Ossipov
Mar 20, 2013·The Journal of Orthopaedic and Sports Physical Therapy·Michael S RathleffLars Arendt-Nielsen
Oct 9, 2013·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Jennifer L DelVenturaJamie L Rhudy
May 28, 2014·Nature Reviews. Rheumatology·David A Walsh, Daniel F McWilliams
Sep 22, 2005·Current Rheumatology Reports·Roger B Fillingim
Jul 15, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Perry G Fine
Nov 12, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ingrid BergströmAgneta Blanck
May 1, 2009·Expert Review of Neurotherapeutics·Costanza Pazzaglia, Massimiliano Valeriani
Mar 11, 2005·Expert Opinion on Emerging Drugs·Susanne D Collins, Iain P Chessell
Sep 26, 2006·Scandinavian Journal of Rheumatology. Supplement·T Graven-Nielsen
Mar 30, 2011·Molecular Pain·Ruth RuscheweyhJürgen Sandkühler
Dec 3, 2013·The Journal of Pain : Official Journal of the American Pain Society·Linda LeRescheMichael Von Korff
Aug 9, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Marc O MartelRobert R Edwards
Sep 18, 2012·The Journal of Pain : Official Journal of the American Pain Society·Gwyn N LewisPeter J McNair
Nov 19, 2011·Best Practice & Research. Clinical Rheumatology·Dan Buskila, Reuven Mader
Nov 19, 2011·Best Practice & Research. Clinical Rheumatology·Lars Arendt-Nielsen, Thomas Graven-Nielsen
Nov 1, 2011·Seminars in Arthritis and Rheumatism·Mira MeeusJo Nijs
May 4, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Peter Czakanski, Timothy J Ness
Dec 4, 2009·Seminars in Arthritis and Rheumatism·David Andrew Rice, Peter John McNair
Jan 16, 2010·The Journal of Pain : Official Journal of the American Pain Society·Gerrit van Wijk, Dieuwke S Veldhuijzen
Apr 22, 2009·The Journal of Pain : Official Journal of the American Pain Society·Lars Arendt-Nielsen, David Yarnitsky
May 17, 2008·The Journal of Pain : Official Journal of the American Pain Society·Claudia M CampbellRoger B Fillingim
Jul 3, 2007·Best Practice & Research. Clinical Rheumatology·Lars Arendt Nielsen, Karl G Henriksson
May 3, 2005·European Journal of Pain : EJP·Birgitte S LaursenLars Arendt-Nielsen
Apr 4, 2006·Arthritis and Rheumatism·Robert R EdwardsJennifer A Haythornthwaite
Aug 5, 2008·The Laryngoscope·Murat ZinnurogluAhmet Köybaşoğlu
Nov 6, 2012·Arthritis and Rheumatism·Yvonne C LeeElizabeth W Karlson
May 5, 2012·Arthritis Care & Research·Daniel F McWilliamsDavid A Walsh

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