Somatosensory system deficits in schizophrenia revealed by MEG during a median-nerve oddball task.

Brain Topography
Ming-Xiong HuangEric Granholm

Abstract

Although impairments related to somatosensory perception are common in schizophrenia, they have rarely been examined in functional imaging studies. In the present study, magnetoencephalography (MEG) was used to identify neural networks that support attention to somatosensory stimuli in healthy adults and abnormalities in these networks in patient with schizophrenia. A median-nerve oddball task was used to probe attention to somatosensory stimuli, and an advanced, high-resolution MEG source-imaging method was applied to assess activity throughout the brain. In nineteen healthy subjects, attention-related activation was seen in a sensorimotor network involving primary somatosensory (S1), secondary somatosensory (S2), primary motor (M1), pre-motor (PMA), and paracentral lobule (PCL) areas. A frontal-parietal-temporal "attention network", containing dorsal- and ventral-lateral prefrontal cortex (DLPFC and VLPFC), orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), superior parietal lobule (SPL), inferior parietal lobule (IPL)/supramarginal gyrus (SMG), and temporal lobe areas, was also activated. Seventeen individuals with schizophrenia showed early attention-related hyperactivations in S1 and M1 but hypo-activation in S1,...Continue Reading

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Citations

Apr 14, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Charles W HuangRoland R Lee
Mar 4, 2014·The Kaohsiung Journal of Medical Sciences·Wei-Hung ChangI-Hui Lee
Mar 15, 2013·Psychiatry Research·Peter TealeMartin Reite
May 23, 2012·Brain Research·Zafiris J DaskalakisPaul B Fitzgerald
Sep 28, 2010·Schizophrenia Research·Wendy HasenkampErica Duncan
Aug 7, 2013·Schizophrenia Research·Je-Yeon YunJun Soo Kwon
May 11, 2016·Translational Psychiatry·G N AndradeJ J Foxe
Jun 5, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Li YaoTao Li
Mar 21, 2019·Frontiers in Psychiatry·Florence HagenmullerWolfram Kawohl
Feb 12, 2021·Journal of Neurophysiology·Junseok A Kim, Karen D Davis
Mar 19, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marta Casquero-VeigaMaría Luisa Soto-Montenegro
Nov 20, 2018·Journal of Neuroscience Methods·Gianvittorio LuriaAlberto Sorrentino

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Methods Mentioned

BETA
PMA
SMA

Software Mentioned

Neuromag
Fieldtrip
Freesurfer
MATLAB
MNE
VESTAL
Elekta

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