PMID: 6113036Jun 9, 1981Paper

Somatostatin-28, somatostatin-14 and somatostatin analogs: effects on thermoregulation

Brain Research
M BrownJ Rivier

Abstract

Somatostatins, somatostatin-14, somatostatin-28, and desAA [D-Trp8]-somatostatin, with differential potencies, act in the brain to reverse chemical-induced hypothermia and to produce hyperthermia. Somatostatins are more potent and loger acting than prostaglandin E2 in producing hyperthermia. Hyperthermia, induced by somatostatins, is not prevented by previous treatment with the prostaglandin synthesis inhibitor indomethacin. Somtostatins given to obese ob/ob mice prevent development of lethal hypothermia and result in maintenance of euthermia. Continuous infusion of somatostatins results in desensitization to the hyperthermic effects of these peptides. Endogenous somatostatins may be involved in regulation of body temperature.

References

May 1, 1974·Journal of the American Chemical Society·J E Rivier
Aug 14, 1980·Biochemical and Biophysical Research Communications·N LingR Guillemin
Jan 1, 1980·Neuroscience and Biobehavioral Reviews·S Yehuda, A J Kastin

❮ Previous
Next ❯

Citations

Mar 1, 1989·Pflügers Archiv : European journal of physiology·M T LinL J Fan
Jan 1, 1983·Pharmacology & Therapeutics·W G Clark, J M Lipton
Jan 1, 1989·Pharmacology & Therapeutics·D WynickS R Bloom
Nov 1, 1983·Regulatory Peptides·R E Burke, S Fahn
Jan 1, 1983·Regulatory Peptides·M R BrownW W Vale
Nov 1, 1983·Peptides·D E Gmerek, A Cowan
May 1, 1983·Peptides·I WakabayashiT Shibasaki
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·L Vécsei, E Widerlöv
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A A ElbadriK D Buchanan
Apr 29, 1998·Brain Research. Developmental Brain Research·M VallarinoR K Rastogi
Oct 1, 1993·Baillière's Clinical Endocrinology and Metabolism·H Yki-Järvinen
May 14, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A StengelY Taché
May 13, 1982·Brain Research·R A Peterfreund, W Vale
Mar 1, 1985·Clinical Endocrinology·R F Casper, S S Yen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.