PMID: 6107910Aug 1, 1980Paper

Somatostatin: an endogenous peptide in the toad urinary bladder inhibits vasopressin-stimulated water flow

Proceedings of the National Academy of Sciences of the United States of America
J N ForrestD B Goodman

Abstract

Somatostatin (somatotropin release-inhibiting factor; SRIF) is a tetradecapeptide present in brain, pancreas, gastrointestinal tract, and thyroid that inhibits the secretion or action of several hormones in these tissues. We observed that the toad urinary bladder contains concentrations of endogenous somatostatin (8.0 pg/micrograms of protein) comparable to those found in the mammalian pancreas and gastrointestinal tract. To determine if somatostatin directly alter the action of vasopressinn we studied the effects of this polypeptide on vasopressin-stimulated transport processes in the toad urinary bladder in vitro. Somatostatin produced a dose-dependent, reversible inhibition of vasopressin-stimulated osmotic water flow; it inhibited theophylline-stimulated osmotic water flow but not the water flow stimulated by 8-p-chlorophenylthioadenosine 3',5'-cyclic monophosphate. These data are consistent with an inhibition of both basal and hormone-stimulated adenylate cyclase. Vasopressin-stimulated short circuit current was not inhibited by somatostatin. These studies provide direct evidence for an effect of somatostatin on hormone-modulated epithelial transport in tissues other than the gastrointestinal tract. We propose that endogen...Continue Reading

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Citations

Jul 1, 1985·Molecular and Cellular Endocrinology·S FujibayashiK Kurokawa
Dec 15, 1983·The New England Journal of Medicine·S Reichlin
May 10, 1984·The New England Journal of Medicine
May 1, 2010·Journal of the American Society of Nephrology : JASN·Marie C HoganVicente E Torres
Nov 28, 2013·World Journal of Gastroenterology : WJG·Andreas BakoyiannisChristos Dervenis
Jun 16, 2005·Kidney International·Piero RuggenentiFranklin H Epstein
Dec 1, 1983·Kidney International·K KurokawaT Yamada
Aug 24, 2010·Autonomic Neuroscience : Basic & Clinical·Phillip Jobling
Dec 18, 2013·Journal of the American Society of Nephrology : JASN·Vicente E Torres, Peter C Harris

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