PMID: 11920496Mar 29, 2002Paper

Somatostatin analogs and prednisone in advanced refractory thymic tumors

Cancer
Giovannella PalmieriSecondo Lastoria

Abstract

Therapeutic options to cure advanced, recurrent, and metastatic thymic tumors are limited. Evidence of a high uptake of indium-labeled octreotide ((111)In-DTPA-D-Phe(1)-octreotide) in thymic tumors and the curative application of somatostatin analogs and prednisone in one patient with thymoma and pure red cell aplasia led the authors to start a Phase II study. Sixteen patients with advanced thymic tumors, unresponsive to conventional chemotherapeutic regimens, were enrolled in the study. The schedule includes administration of somatostatin analog octreotide (1.5 mg/day subcutaneously) associated with prednisone (0.6 mg/kg/day orally for 3 months, 0.2 mg/kg/day orally during follow-up). In 8 cases, octreotide was replaced by the long-acting analog lanreotide (30 mg/every 14 days intramuscolarly). Treatment was prolonged until progression of disease was documented. Overall response rate, survival, progression free survival, and toxicity were evaluated. The overall response rate among 16 evaluable patients was 37%. One patient (6%) had a complete response, 5 (31%) had a partial response, 6 obtained a stabilization of disease, and 4 progressed during the treatment. After a median follow-up of 43 months, the median survival was 15 m...Continue Reading

References

Jul 1, 1991·Cancer·A FornasieroM V Fiorentino
Jun 1, 1986·Cellular Immunology·M DardenneF Homo-Delarche
Aug 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T E WitzigH E Windschitl
Jan 25, 1996·The New England Journal of Medicine·S W LambertsL J Hofland
Jan 23, 1997·The New England Journal of Medicine·G PalmieriM Salvatore
Feb 19, 1998·Medical Oncology·N JanP H Wiernik
Mar 26, 1998·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·T SudaR Hoshino
Mar 28, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P KognerM Hassan
Apr 16, 1998·American Journal of Clinical Oncology·A SandlerR Dreicer
Jul 21, 1998·Annals of Internal Medicine·D M ShinW K Hong
Sep 2, 1998·Endocrinology·V de Mello-CoelhoM C Postel-Vinay
Sep 16, 1998·The American Journal of Surgical Pathology·L LauriolaJ Rosai
Aug 26, 1999·The British Journal of Ophthalmology·J M MAcKENZIE
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A N WymengaK E Oberg
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C R ThomasP J Loehrer
Oct 24, 2000·The British Journal of Surgery·K H KhalilD Sellu

❮ Previous
Next ❯

Citations

Sep 22, 2005·Surgery Today·Philipp StröbelHans Konrad Müller-Hermelink
Aug 11, 2007·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Z R GaoS Ezziddin
Apr 14, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·D FeroneL J Hofland
Dec 12, 2003·The Annals of Thoracic Surgery·Federico VenutaGiorgio F Coloni
May 25, 2007·The New England Journal of Medicine·Cameron D WrightRobert P Hasserjian
Nov 3, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G PalmieriG Di Lorenzo
Aug 8, 2006·American Journal of Clinical Oncology·Giuseppe GiacconePaul van der Valk
Feb 18, 2011·American Journal of Clinical Oncology·Flavia LongoCamillo Furio Coloni
Nov 7, 2007·Journal of Pediatric Hematology/oncology·Gabriella P KerteszMiklos Garami
Dec 21, 2004·Chemotherapy·Tetsuya OguriRyuzo Ueda
Dec 21, 2013·Cancer Treatment Reviews·Rossana BerardiStefano Cascinu
Dec 14, 2007·Journal of Endocrinological Investigation·P AmeriD Ferone
Jan 13, 2012·General Thoracic and Cardiovascular Surgery·Federico VenutaGiorgio F Coloni
Jul 27, 2007·Acta Oncologica·Renata ZauchaJacek Jassem
May 19, 2012·Expert Review of Anticancer Therapy·Nicolas Girard
Jul 16, 2010·Expert Opinion on Investigational Drugs·Glen J Weiss
Nov 14, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Alberto SandriEnrico Ruffini
Jun 27, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Conrad B FalksonUNKNOWN Lung Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-Based Care
Feb 4, 2014·Clinical Lung Cancer·Paul Wheatley-PriceMarcio M Gomes
Jan 17, 2012·Cancer Treatment Reviews·Hannah KoppitzIngo G H Schmidt-Wolf
Nov 13, 2010·Thoracic Surgery Clinics·Mirella Marino, Mauro Piantelli
Dec 17, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Michael RiedHans-Stefan Hofmann
Aug 18, 2004·Clinical Lung Cancer·Anupama Kurup, Patrick J Loehrer
Jun 3, 2008·Hematology/oncology Clinics of North America·Erin M CaseyPatrick J Loehrer
May 1, 2007·The Lancet Oncology·Gabriella FarinaAlberto Scanni
Jul 21, 2006·Annals of the New York Academy of Sciences·Diego FeroneFrancesco Minuto
Mar 26, 2011·Cancer·Takahiro MimaeHitoshi Tsuda
Oct 9, 2015·The New England Journal of Medicine·Panos M FidiasLawrence R Zukerberg
Aug 16, 2005·Seminars in Nuclear Medicine·Diego FeroneSecondo Lastoria
Apr 9, 2016·Cancer Treatment Reviews·J RemonB Besse
Apr 28, 2004·The Annals of Thoracic Surgery·Frank C Detterbeck, Alden M Parsons
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N GirardUNKNOWN ESMO Guidelines Committee
Jun 17, 2005·Expert Opinion on Pharmacotherapy·Kyriakos P Papadopoulos, Charles R Thomas
Nov 21, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D SerpicoUNKNOWN TYME (TYmic MalignanciEs) Collaborative Group
May 23, 2014·Frontiers in Oncology·Yuanbin ChenAnish Thomas
Mar 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M TiseoA Ardizzoni
Feb 26, 2003·Annals of Hematology·I G H Schmidt-WolfD Huhn
Sep 5, 2006·The Oncologist·Richard F Riedel, William R Burfeind
Aug 11, 2017·Current Treatment Options in Oncology·Claire Merveilleux du VignauxNicolas Girard
May 28, 2020·Frontiers in Oncology·Matthew C L PhillipsBen G Moon
Sep 29, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Ondrej SorejsOndrej Fiala
Feb 28, 2021·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Fabrizio CitarellaGiuseppe Tonini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
P J LoehrerEastern Cooperative Oncology Group Phase II Trial
Annals of Oncology : Official Journal of the European Society for Medical Oncology
C ChristodoulouD Skarlos
© 2022 Meta ULC. All rights reserved