PMID: 6111117Jan 1, 1980Paper

Somatostatin and gastrin release from canine stomach

Scandinavian Journal of Gastroenterology
H KoopW Creutzfeldt

Abstract

Somatostatin and gastrin release into the veins draining the stomach was studied in 27 anaesthetized dogs. Basal somatostatin-like immunoreactivity (SLI) in corpus veins (136 +/- 36 pg/ml) was significantly higher than in antrum veins (83 +/- 20 pg/ml; p less than 0.05) and the femoral artery (58 +/- 15 pg/ml; p less than 0.02). During peptone, pH 6.5, perfusion of the stomach, SLI concentration increased significantly in the corpus veins to approximately four times basal and in the antrum veins to three times basal, whereas SLI levels in the peripheral circulation remained constant. Peptone, pH 3.5, and sodium oleate did not stimulate gastric SLI. Gastric distension increased significantly SLI release from the corpus. In gel filtration studies 50%--70% of SLI from gastric vein plasma samples but greater than 90% from femoral artery samples eluted in the void volume of Sephadex G-25 columns. Gastrin secretion was stimulated significantly only by peptone, pH 6.5.

References

Jan 1, 1979·Annals of Clinical Biochemistry·E PenmanL H Rees
Jun 1, 1978·Acta Endocrinologica·S Gustavsson, G Lundquist
Jul 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·V HarrisR H Unger
Sep 1, 1978·Metabolism: Clinical and Experimental·A ArimuraC Meyers
Sep 1, 1978·Metabolism: Clinical and Experimental·C McIntoshW Creutzfeldt
Dec 1, 1978·The Journal of Clinical Investigation·J M ConlonR H Unger
Mar 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·A ArimuraA V Schally

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Citations

Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H KoopR Arnold
Mar 1, 1986·Regulatory Peptides·H SchwartingR Arnold
May 12, 1998·The American Journal of Physiology·Y ZavrosA Shulkes

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