PMID: 45065Oct 1, 1979

Somatostatin and insulin secretion in man. II. The effect of theophylline

Acta diabetologica latina
D GiuglianoS Sgambato

Abstract

This study was aimed at evaluating the effect of theophylline, a drug that increases the intracellular concentrations of cAMP by inhibiting phosphodiesterase activity, on somatostatin (SRIF)-mediated inhibition of insulin secretion in man. Acute insulin response (AIR) to i.v. glucose (mean change 3-10 min) was almost totally suppressed by SRIF (500 micrograms/h) and glucose utilization was reduced (p less than 0.0001). These SRIF-induced decreases failed to be eliminated by a concurrent infusion of theophylline (100 mg as a loading dose followed by a constant infusion of 5 mg/min). Theophylline alone resulted in a significant increase in both AIR (p less than 0.01) and glucose removal rates (p less than 0.05). Thus, our data disprove the involvement of the phosphodiesterase enzymes in the inhibitory action of SRIF on glucose-induced insulin secretion in man.

References

Sep 1, 1980·Acta Physiologica Scandinavica·P Hellstrand, J Järhult

Citations

Jan 1, 1978·Annual Review of Biochemistry·A V SchallyC A Meyers
Oct 6, 1975·Biochemical and Biophysical Research Communications·T TaminatoH Imura
Aug 1, 1978·Metabolism: Clinical and Experimental·A KanetoK Kosaka
Sep 1, 1978·Metabolism: Clinical and Experimental·H J HahnP Woltanski
Sep 1, 1978·Metabolism: Clinical and Experimental·G J TaborskyD Porte
Sep 1, 1978·Metabolism: Clinical and Experimental·C B WollheimG W Sharp
May 1, 1977·The Journal of Clinical Endocrinology and Metabolism·W WaldhäuslE Deutsch
Feb 10, 1976·Biochemistry·A V SchallyD H Schlesinger
Oct 8, 1974·Biochemical and Biophysical Research Communications·D L Curry, L L Bennett
Feb 18, 1967·Nature·J R TurtleD M Kipnis
Jan 1, 1980·Pharmacological Research Communications·D GiuglianoS Sgambato

Related Concepts

Enzymes, antithrombotic
Phosphoric diester hydrolase
Protoplasm
Inhibition of Insulin Secretion
Insulin B Chain
Enzymes for Treatment of Wounds and Ulcers
Theophylline
Theophylline Assay
Monospan
SSTR2

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