Somatostatin and its receptors from fish to mammals

Annals of the New York Academy of Sciences
Manuel D GaheteJusto P Castaño

Abstract

Somatostatin (SST) and its receptors (sst) make up a molecular family with unique functional complexity and versatility. Widespread distribution and frequent coexpression of sst subtypes underlies the multiplicity of (patho)physiological processes controlled by SST (central nervous system functions, endocrine and exocrine secretion, cell proliferation). This complexity is clearly reflected in the intricate evolutionary development of this molecular family. Recent studies postulate the existence of an ancestral somatostatin/urotensin II (SST/UII) gene, which originated two ancestral, SST and UII, genes by local duplication. Subsequently, segment duplication would have originated two diverging SST genes in both fish (SS1/SS2) and tetrapods [(SST/cortistatin(CST))]. SST/CST actions are mediated by a family of GPCRs (sst1-5) encoded by five different genes. sst1-4 sequences are highly conserved compared with sst5, suggesting unique evolutionary and functional relevance for the latter. Indeed, we recently identified novel truncated but functional sst5 variants in several species, which may help to explain part of the complexity of the SST/CST/sst family. Comparative and phylogenetic analysis of this molecular family would enhance ou...Continue Reading

References

Jan 1, 1986·General and Comparative Endocrinology·P Langhorne
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·G S SpencerS Kestin
Apr 1, 1984·General and Comparative Endocrinology·A F Cook, R E Peter
Jan 1, 1995·General and Comparative Endocrinology·P MelamedZ Naor
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·H TostivintH Vaudry
Jan 1, 1997·Proceedings of the Society for Experimental Biology and Medicine·W H YuS M McCann
Aug 1, 1997·The Journal of Endocrinology·M M Piper, T E Porter
Aug 6, 1999·Frontiers in Neuroendocrinology·Y C Patel
Mar 3, 2001·Journal of Endocrinological Investigation·R DeghenghiG Muccioli
Oct 3, 2002·Biochemical and Biophysical Research Communications·Maria C ZatelliEttori C degli Uberti
Jan 4, 2003·Molecular Endocrinology·Mathias Z StrowskiHilary A Wilkinson
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Virgil A DalmLeo J Hofland
Apr 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Virgil A S H DalmLeo J Hofland
Jun 19, 2003·General and Comparative Endocrinology·Kris L GerisVeerle M Darras
Aug 14, 2003·The Journal of Biological Chemistry·Nicola RobasMark Fidock
Sep 26, 2003·Biochimica Et Biophysica Acta·Lars Neisig MøllerJens Juul Holst
May 19, 2004·Journal of Neurochemistry·Gisela OliasWolfgang Meyerhof
Aug 25, 2004·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Mark A Sheridan, Jeffrey D Kittilson
Feb 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hervé TostivintHubert Vaudry
Feb 24, 2006·The Journal of Experimental Medicine·Elena Gonzalez-ReyMario Delgado
Apr 6, 2006·The Journal of Clinical Endocrinology and Metabolism·Hadara RubinfeldIlan Shimon
Jul 11, 2006·American Journal of Physiology. Endocrinology and Metabolism·Raul M LuqueRhonda D Kineman

❮ Previous
Next ❯

Citations

Apr 18, 2014·Journal of Molecular Endocrinology·Hervé TostivintDan Larhammar
Aug 19, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Florian FreudenbergWilliam H J Norton
Jul 29, 2015·Diabetologia·Rafael Arrojo e DrigoBernhard O Boehm
Aug 3, 2013·Developmental Cell·Laura Lleras-ForeroAndrea Streit
Dec 24, 2014·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Xiu FengJingou Tong
Aug 16, 2016·General and Comparative Endocrinology·Hervé TostivintNatalia B Kenigfest
Sep 13, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Huan WangXiaobing Wu
Apr 20, 2013·American Journal of Public Health·Roxana Z WitterJohn Adgate
Feb 6, 2017·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Alejandro Ibáñez-CostaJusto P Castaño
Jan 18, 2017·Journal of Neurogastroenterology and Motility·Philip Prinz, Andreas Stengel
Feb 15, 2018·The Journal of Experimental Biology·Maurice R ElphickDan Larhammar
Aug 25, 2017·The Journal of Endocrinology·Alejandro Ibáñez-Costa, Márta Korbonits
Dec 26, 2013·American Journal of Physiology. Endocrinology and Metabolism·Manuel D GaheteJusto P Castaño
Jul 11, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Quan Jiang, Anderson O L Wong
Apr 11, 2020·International Journal of Molecular Sciences·Ujendra Kumar, Sneha Singh
Jun 6, 2020·Journal of Clinical Medicine·Prudencio Sáez-MartínezRaúl M Luque
Apr 16, 2019·Frontiers in Physiology·Zbigniew AdamskiGrzegorz Rosiński
May 18, 2018·Frontiers in Neuroscience·Ruifang HuaHaohong Li
Feb 4, 2021·Brain Structure & Function·D Sobrido-CameánA Barreiro-Iglesias
Jul 3, 2021·International Journal of Molecular Sciences·Lian Hollander-CohenBerta Levavi-Sivan
Jul 18, 2020·Current Topics in Medicinal Chemistry·Worood Sirhan, Ron Piran

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.