PMID: 9440032Jan 24, 1998Paper

Somatostatin and somatostatin receptors in the diagnosis and treatment of gliomas

Journal of Neuro-oncology
K LamszusM Westphal

Abstract

Somatostatin analogues are in clinical use for the diagnosis and treatment of several oncological indications, namely pituitary adenomas and endocrine gastrointestinal tumors. In addition for a variety of malignancies their potential value is being studied. It has been speculated that somatostatin plays a role in the homeostasis of gliomas, and that gliomas could be susceptible to antiproliferative effects of somatostatin analogues. These assumptions were tested in 20 human cell lines derived from malignant gliomas and 4 glioblastoma tissue specimens, which were analyzed for their expression of the five known somatostatin receptor genes (SSTR1-5) and for the receptor function. Using semiquantitative PCR techniques, SSTR2 transcripts were found in all 20 cell lines and 4 glioblastomas, SSTR1 transcripts were detected in 9 cell lines and 4 glioblastomas, and SSTR3 transcripts were noted in 7 cell lines and 1 glioblastoma. SSTR4 and SSTR5 transcripts were only rarely detected. Gene expression profiles in glioblastoma tissue specimens resembled those of the cell lines in quality as well as quantity, with average transcript levels being highest for the SSTR2, followed by SSTR1 and SSTR3. However, when compared to GH3 anterior pituit...Continue Reading

Citations

Oct 31, 2012·Journal of Peptide Science : an Official Publication of the European Peptide Society·Kakali DeMridula Misra
Jun 6, 2002·Journal of Neuroendocrinology·P CerveraJ Epelbaum
Apr 18, 2001·International Journal of Cancer. Journal International Du Cancer·J GuyotatM Fevre Montange
Apr 27, 2018·Journal of Cancer Research and Clinical Oncology·Franziska LangeAmelie Lupp
Mar 12, 2013·International Journal of Peptides·Federica BarbieriTullio Florio
May 8, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael C FrühwaldHermann L Müller
Nov 23, 2000·Journal of Physiology, Paris·J Held-FeindtR Mentlein
Feb 27, 2001·Brain Research. Molecular Brain Research·J Held-FeindtR Mentlein

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