Somatostatin attenuates microcirculatory impairment in acute sodium taurocholate-induced pancreatitis

Digestive Diseases and Sciences
T PlusczykG Feifel

Abstract

Using in vivo microscopy, red blood cell (RBC) velocities, functional capillary density (FCD), and overall changes in capillary blood flow (PI) were estimated following intraductal infusion of sodium taurocholate (0.8 ml; 4%) alone or in combination with systemic administration of somstostatin (single bolus SMS 100 microg/100 g body wt). Sodium taurocholate mediated a significant transient decrease in RBC velocities and a sustained decrease in FCD, which were paralleled by dramatic flow heterogeneity. Therefore, a significant reduction in overall capillary blood flow was calculated. Additional SMS treatment reduced microcirculatory impairment as expressed by reduction of blood flow heterogeneity, a less rarified functional capillary density, and a recovery of RBC velocities and acinar capillary overall perfusion to control values. As a result of this microcirculatory improvement, pancreas histology revealed slightly less severe tissue damage compared to the non-SMS-treated pancreatitis group. These findings demonstrate that exogenous SMS infusion can improve microcirculatory failure in acute biliary pancreatitis, which should have a beneficial effect on the course of the disease.

Citations

Jun 5, 2002·World Journal of Gastroenterology : WJG·Zong-Guang Zhou, You-Dai Chen
Jan 15, 2008·Pancreas·Christine M CuthbertsonChristopher Christophi
Jan 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Klaus-D SchaserUtz Settmacher
Apr 12, 2006·The British Journal of Surgery·C M Cuthbertson, C Christophi
Mar 26, 2008·Pancreas·Mark E Brooke-SmithGino T P Saccone
Oct 16, 2002·World Journal of Gastroenterology : WJG·Zong-Guang ZhouZhong Chen
Jul 4, 2006·ANZ Journal of Surgery·Christine M Cuthbertson, Christopher Christophi
Aug 1, 2015·The Journal of Obstetrics and Gynaecology Research·Nuri YildirimOytun Erbas
Jul 18, 2000·The Journal of Surgical Research·M HeuserS Post
May 12, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Haki KaraAziz Karaoglu

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